原著論文

2022年

15. Akiyama, M., Unoki, T., Aoki, H., Nishimura, A., Shinkai, Y., Warabi, E., Nishiyama, K., Furumoto, Y., Anzai, N., Akaike, T., Nishida, M., Kumagai, Y. (2022). Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress. Redox Biol. in press.
    DOI: 10.1016/j.redox.2022.102506
16. Fujimura, M., Unoki, T. (2022). Preliminary evaluation of the mechanism underlying vulnerability/resistance to methylmercury toxicity by comparative gene expression profiling of rat primary cultured cerebrocortical and hippocampal neurons. J. Toxicol. Sci. 47, 211-219.
    DOI: 10.2131/jts.47.211
17. Horai, S., Abiko, Y., Unoki, T., Shinkai, Y., Akiyama, M., Nakata, K., Kunisue, T., Kumagai, Y. (2022). Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan. Chemosphere 133833.
    DOI: 10.1016/j.chemosphere.2022.133833
18. Unoki, T., Akiyama, M., Shinkai, Y., Kumagai, Y., Fujimura, M. (2022). Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain. J. Toxicol. Sci. 47, 31-37.
    DOI: 10.2131/jts.47.31　論文紹介

2020年

11. Fujimura, M., Usuki, F., Unoki, T. (2020). Decreased plasma thiol antioxidant capacity precedes neurological signs in a rat methylmercury intoxication model. Food Chem. Toxicol. 146, 111810.
    DOI: 10.1016/j.fct.2020.111810　論文紹介
12. Akiyama, M., Unoki, T., Yoshida, E., Ding,Y., Yamakawa, H., Shinkai, Y., Ishii, I., Kumagai, Y. (2020). Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain. Toxicol. Lett. 330, 128-133.
    DOI: 10.1016/j.toxlet.2020.05.007
13. Akiyama, M., Unoki, T., Kumagai,Y. (2020). Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide. Fundam. Toxicol. Sci. 7, 161-166.
    DOI: 10.2131/fts.7.161

2019年

8. Akiyama, M., Unoki, T., Shinkai, Y., Ishii, I., Ida, T., Akaike, T., Yamamoto, M., Kumagai, Y. (2019). Environmental electrophile-mediated toxicity in mice lacking Nrf2, CSE, or both. Environ. Health Perspect. 127, 67002.
   DOI: 10.1289/EHP4949 論文紹介

2017年

7. Akiyama, M., Shinkai, Y., Unoki, T., Shim, I., Ishii, I., and Kumagai, Y. (2017). The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity. Chem. Res. Toxicol. 30, 2209-2217.
   DOI: 10.1021/acs.chemrestox.7b00278
8. Abiko, Y., Shinkai, Y., Unoki, T., Hirose, R., Uehara, T., and Kumagai, Y. (2017). Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts. Sci. Rep. 7, 4814.
   DOI: 10.1038/s41598-017-04590-z
9. Abiko, Y., Sha, L., Shinkai, Y., Unoki, T., Luong, N.C., Tsuchiya, Y., Watanabe, Y., Hirose, R., Akaike, T., and Kumagai, Y. (2017). 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides. Free Radic. Biol. Med. 104, 118-128.
   DOI: 10.1016/j.freeradbiomed.2016.12.047

2016年

4. Unoki, T., Abiko, Y., Toyama, T., Uehara, T., Tsuboi, K., Nishida, M., Kaji, T., and Kumagai, Y. (2016). Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells. Sci. Rep. 6, 28944.
   DOI: 10.1038/srep28944

2012年

3. Hasegawa, H., Noguchi, J., Yamashita, M., Okada, R., Sugimoto, R., Furuya, M., Unoki, T., Funakoshi, Y., Baba, T., and Kanaho, Y. (2012). Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis. Biol. Reprod. 86, 136, 131-112.
   DOI: 10.1095/biolreprod.110.089896
4. Unoki, T., Matsuda, S., Kakegawa, W., Van, N.T., Kohda, K., Suzuki, A., Funakoshi, Y., Hasegawa, H., Yuzaki, M., and Kanaho, Y. (2012). NMDA receptor-mediated PIP5K activation to produce PI(4,5)P2 is essential for AMPA receptor endocytosis during LTD. Neuron 73, 135-148.
   DOI: 10.1016/j.neuron.2011.09.034　F1000Prime Recommended

2007年

1. Nakano-Kobayashi, A., Yamazaki, M., Unoki, T., Hongu, T., Murata, C., Taguchi, R., Katada, T., Frohman, M.A., Yokozeki, T., and Kanaho, Y. (2007). Role of activation of PIP5Kγ661 by AP-2 complex in synaptic vesicle endocytosis. EMBO J. 26, 1105-1116.
   DOI: 10.1038/sj.emboj.7601573

総説

2020年

4. Unoki, T., Akiyama, M., Kumagai, Y. (2020). Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress. Int. J. Mol. Sci. 21, 545.
   DOI: 10.3390/ijms21020545　論文紹介

2019年

3. Kumagai, Y., Akiyama, M., Unoki, T. (2019). Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules. Toxicol. Res. 35, 303-310.
   DOI: 10.5487/TR.2019.35.4.303

2018年

2. Unoki, T., Akiyama, M., Kumagai, Y., Gonçalves, F.M., Farina, M., da Rocha, J.B.T., Aschner, M. (2018). Molecular pathways associated with methylmercury-induced Nrf2 modulation. Front. Genet. 9, 373.
   DOI: 10.3389/fgene.2018.00373

2012年

1. Kanaho, Y., and Unoki, T. (2012). Regulation and functions of the lipid kinase PIP5Kγ661 at synapses. Adv. Enzyme Regul. 52, 59-65.

その他

2019年

1. 鵜木隆光 (2019) トピックス「白金薄膜電極を用いた水中からの水銀の高効率な除去」ファルマシア. 55, 704.
   DOI: 10.14894/faruawpsj.55.7_704