Our organization, departments, staff and researchers
Mineshi Sakamoto
The research group I work for : Risk Assessment Group
Specialty: Environmental Epidemiology, Toxicological Neuroethology I have been primarily engaged in research on the fetal effects of methylmercury for over 30 years. In an epidemiological study of fetuses, which have the highest sensitivity to methylmercury, I found that boys were more vulnerable to methylmercury contamination than girls, and that excess deaths of boys due to stillbirths and miscarriages reduced the ratio of male to female births in Minamata City. I also published a paper showing that methylmercury is actively transferred via the placenta, accumulating in fetal blood and brain at higher concentrations than in the mother, and that it is less likely to be transferred from breast milk. These findings were adopted as the scientific evidence for the 2005 Ministry of Health, Labour and Welfare (MHLW) decision on "Precautions for Seafood Consumption by Pregnant Women in Consideration of Possible Effects on the Fetus.” On the other hand, based on the fact that fish contains docosahexaenoic acid (DHA), which is beneficial to the fetal brain, the American Chemical Society Science News featured the recommendation that pregnant women should eat small fish rich in DHA and low in mercury to help protect their children's brains. Currently, I am working diligently to investigate a new aspect of Minamata disease: the elevated selenium concentration in Minamata disease patients and the role of selenium in the pathogenesis of the disease, which remained a mystery for many years. In 2017, I received the Presidential Award of the National Personnel Authority (individual category) in recognition of my contributions to Minamata disease research, as well as my international contributions to solving numerous mercury contamination problems overseas in response to urgent requests from the World Health Organization (WHO) and others.
Overseas surveys and investigations: Field surveys at the request of WHO (Kyrgyzstan, Cambodia, Indonesia, Mongolia); cooperation for investigation of mercury pollution due to a factory fire in Hanoi, Vietnam Cooperation to JICA (Philippines, Brazil, Bangladesh); international joint studies (Brazil, China, USA, Canada, Slovenia, Spain, Philippines, Italy, Vietnam, Mongolia)
Research subjects and areas of work (principal roles only)
Study on the coexistence of mercury and selenium in Minamata disease and the effects of methylmercury on fetuses and infants
Main research achievements
English: Original articles and reviews
2022
Sakamoto M, Haraguchi K, Tatsuta N, Marumoto M, Yamamoto M, Nakamura M. Breast milk contribution to tissue mercury levels in rat pups examined by cross-fostering at birth. Environ Res. (IF=8.431) 2022 Jan 19; 208: 112772. Online first.
Marumoto M, Sakamoto M, Nakamura M, Marumoto K, Tsuruta S. Organ-specific accumulation of selenium and mercury in Indo-Pacific bottlenose dolphins (Tursiops aduncus). Acta Vet Scand. (IF=1.695) 2022 Jan 27; 64(1): 1.
2021
Sakamoto M, Haraguchi K, Tatsuta N, Nakai K, Nakamura M, Murata K. Plasma and red blood cells distribution of total mercury, inorganic mercury, and selenium in maternal and cord blood from a group of Japanese women. Environ Res. (IF=8.431) 2021 May; 196: 110896.
2020
Sakamoto M, Kakita A, Sakai K, Kameo S, Yamamoto M, Nakamura M. Methylmercury exposure during the vulnerable window of the cerebrum in postnatal developing rats. Environ Res. (IF=8.431) 2020 Sep; 188: 109776.
Sakamoto M, Itai T, Marumoto K, Marumoto M, Kodamatani H, Tomiyasu T, Nagasaka H, Mori K, Poulain AJ, Domingo JL, Horvat M, Matsuyama A: Mercury speciation in preserved historical sludge: Potential risk from sludge contained within reclaimed land of Minamata Bay, Japan. Environ Res. (IF=8.431), 2020 Jan; 180: 108668. (JSPS KAKENHI Grant Number JP15K00533)
Yamamoto M, Yanagisawa R, Sakai A, Mogi M, Shuto S, Shudo M, Kashiwagi H, Kudo M, Nakamura M, Sakamoto M. Toxicokinetics of methylmercury in diabetic KK-Ay mice and C57BL/6 mice. J Appl Toxicol (IF=3.446). 2020 Oct 5.
Tatsuta N, Nakai K, Kasanuma Y, Iwai-Shimada M, Sakamoto M, Murata K, Satoh H. Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children. Environ Res. (IF=8.431) 2020 Oct; 189: 109844.
Marumoto M, Sakamoto M, Marumoto K, Tsuruta S, Komohara Y. Mercury and Selenium Localization in the Cerebrum, Cerebellum, Liver, and Kidney of a Minamata Disease Case. Acta Histochem Cytochem. (IF=1.75) 2020; 53 (6): 147–155.
Haraguchi K, Sakamoto M, Matsuyama A, Yamamoto M, Hung DT, Nagasaka H, Uchida K, Ito Y, Kodamatani H, Horvat M, Chan HM, Rand M, Cirtiu CM, Kim BG, Nielsen F, Yamakawa A, Mashyanov N, Panichev N, Panova E, Watanabe T, Kaneko N, Yoshinaga J, Herwati RF, Suoth AE, Akagi H. Development of Human Hair Reference Material Supporting the Biomonitoring of Methylmercury. Anal Sci. 2020 May 10;36 (5):561-567.
2019
Maeda E, Murata K, Kumazawa Y, Sato W, Shirasawa H, Iwasawa T, Izumo K, Tatsuta N, Sakamoto M, Terada Y. Associations of environmental exposures to methylmercury and selenium with female infertility: A case-control study. Environ Res. (IF=8.431) 2019 Jan; 168: 357-363.
2018
Sakamoto M, Tatsuta N, Chan HM, Domingo JL, Murata K, Nakai K. Brain methylmercury uptake in fetal, neonate, weanling, and adult rats. Environ Res. (IF=8.431) 2018 Nov; 167: 15-20.
Karita K, Iwata T, Maeda E, Sakamoto M, Murata K. Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity. Toxics (IF=4.146). 2018 Jul 20; 6(3). pii: E38.
Sakamoto M, Chan HM, Domingo JL, Koriyama C, Murata K. Placental transfer and levels of mercury, selenium, vitamin E, and docosahexaenoic acid in maternal and umbilical cord blood. Environ Int. (IF=13.352) 2018 Feb; 111:309-315.
Sakamoto M, Tatsuta N, Izumo K, Phan P T, Vu L D, Yamamoto M, Nakamura M, Nakai K, Murata K. Health impacts and biomarkers of prenatal exposure to methylmercury: Lessons from Minamata, Japan Toxics (IF=4.146). 2018 Aug 3;6(3):45
Tatsuta N, Nakai N, Sakamoto M, Murata K, Satoh H. Methylmercury exposure and developmental outcomes in Tohoku Study of Child Development at 18 months of age.Toxics (IF=4.146) 2018, 6(3), 49
2017
Hoang VAT, Sakamoto M, Yamamoto M. Mercury and selenium levels, and their molar ratios in several species of commercial shrimp in Japan regarding the health risk of methylmercury exposure. J Toxicol Sci. (IF=1.719) 2017; 42(4):509-517.
Hoang VAT, Do HTT, Agusa T, Koriyama C, Akiba S, Ishibashi Y, Sakamoto M, Yamamoto M. Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi. J Toxicol Sci. (IF=1.719) 2017; 42(5):651-662.
Sakamoto M, Kakita A, Domingo JL, Yamazaki H, Oliveira R, Sarrazine S, Eto K, Murata K. Stable and episodic/bolus patterns of methylmercury exposure on mercury accumulation and histopathologic alterations in the nervous system. Environ Res. (IF=8.431) 2017 Jan; 152: 446-453.
Ser PH, Omi S, Shimizu-Furusawa H, Yasutake A, Sakamoto M, Hachiya N, Konishi S, Nakamura M, Watanabe C. Differences in the responses of three plasma selenium-containing proteins in relation to methylmercury-exposure through consumption of fish/whales. Toxicol Lett. (IF=3.166) 2017 Feb 5; 267:53-58.
Ha E, Basu N, Bose-O'Reilly S, Dórea JG, McSorley E, Sakamoto M, Chan HM. Current progress on understanding the impacts of mercury on human health. Environ Res. (IF=8.431) 2017 Jan; 152:419-433.
2016
Iwata T, Takaoka S, Sakamoto M, Maeda E, Nakamura M, Liu XJ, Murata K. Characteristics of hand tremor and postural sway in patients with fetal-type Minamata disease. J Toxicol Sci. (IF=1.719) 2016; 41(6):757-763.
Sakamoto M, Murata K, Domingo JL, Yamamoto M, Oliveira RB, Kawakami S, Nakamura M. Implications of mercury concentrations in umbilical cord tissue in relation to maternal hair segments as biomarkers for prenatal exposure to methylmercury. Environ Res. (IF=8.431) 2016 Aug; 149:282-7.
2015
Sakamoto M, Chan HM, Domingo JL, Oliveira RB, Kawakami S, Murata K. Significance of fingernail and toenail mercury concentrations as biomarkers for prenatal methylmercury exposure in relation to segmental hair mercury concentrations. Environ Res. (IF=8.431) 2015 Jan; 136:289-94.
Sakamoto M, Itai T, Yasutake A, Iwasaki T, Yasunaga G, Fujise Y, Nakamura M, Murata K, Chan HM, Domingo JL, Marumoto M. Mercury speciation and selenium in toothed-whale muscles. Environ Res. (IF=8.431) 2015 Nov; 143(Pt A):55-61.
Ilmiawati C, Yoshida T, Itoh T, Nakagi Y, Saijo Y, Sugioka Y, Sakamoto M, Ikegami Ogawa A, M, Kayama F. Biomonitoring of mercury, cadmium, and lead exposure in Japanese children: a cross-sectional study. Environ Health Prev Med. (IF=3.674) 2015 Jan; 20(1):18-27.
2014
Yamamoto M, Yanagisawa R, Motomura E, Nakamura M, Sakamoto M, Takeya M, Eto K. Increased methylmercury toxicity related to obesity in diabetic KK-Ay mice. J Appl Toxicol. (IF=3.446) 2014 Aug; 34(8):914-23.
Nakamura M, Hachiya N, Murata KY, Nakanishi I, Kondo T, Yasutake A, Miyamoto K, Ser PH, Omi S, Furusawa H, Watanabe C, Usuki F, Sakamoto M. Methylmercury exposure and neurological outcomes in Taiji residents accustomed to consuming whale meat. Environ Int. (IF=13.352) 2014 Jul; 68:25-32.
Arai K, Maeda E, Iwata T, Tanaka O, Murata K and Sakamoto M. Impact of dietary behaviors on dyslipidemia in Japanese male workers. Ann Transl Med Epidemiol. 2014; 1(1):1003.
2013
Sakamoto M, Yasutake A, Domingo JL, Chan HM, Kubota M, Murata K. Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue: Potential use as indicators for prenatal exposure. Environ Int. (IF=13.352) 2013 Sep 9; 60C: 106-111.
Horvat M, Sakamoto M, Chan L, Faganeli J. Mercury in contaminated sites: identification, characterization, impacts, and remediation. Environ Res. (IF=8.431) 2013 Aug; 125:1.
Sakamoto M, Yasutake A, Kakita A, Ryufuku M, Chan HM, Yamamoto M, Oumi S, Kobayashi S, Watanabe C. Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat cerebrum. Environ Sci Technol. (IF=11.357). 2013 Mar 19; 47(6):2862-8.
2012
Sakamoto M, Chan HM, Domingo JL, Kubota M, Murata K. Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer. Ecotox Environ Safety (IF=7.179) 2012 Oct; 84:179-84.
Sakamoto M, Murata K, Kakita A, Sasaki M. A review of mercury toxicity with special reference to methylmercury, in:Advances in Environmental Chemistry and Toxicology of Mercury (Cai Y, Liu G, O'Driscoll N eds.), Wiley-VCH (Weinheim), 2012 pp. 501-516 Chapter 15.
Murata K, Sakamoto M. Minamata disease.In: Nriagu JO(ed.) Encyclopedia of Environmental Health, 2012 vol 3:774-780, Burlington: Elsevier.
Sakamoto M, Chan HM, Domingo JL, Kawakami S, Murata K. Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition. Environ Int. (IF=13.352)) 2012 Sep; 44:112-7.
2011
Steckling N, Boese-O'Reilly S, Sakamoto M (12th), (plus 16 co-authors). Mercury exposure in female artisanal small-scale gold miners (ASGM) in Mongolia: An analysis of human biomonitoring (HBM) data from 2008. Sci Total Environ. (IF=7.963) 2011 Feb 1; 409(5):994-1000.
2010
Sakamoto M, Murata K, Tsuruta K, Miyamoto K, Akagi H. Retrospectve study on temporal and regional variations of methylmercury concentrations in preserved umbilical cords collected from inhabitants of the Minamata area, Japan. Ecotox Environ Safety (IF=7.179). 2010 Sep; 73(6):1144-9.
Sakamoto M, Murata K, Kubota M, Nakai K, Satoh H. Mercury and heavy metal profiles of maternal and umbilical cord RBCs in Japanese population. Ecotox Environ Safety (IF=7.179) 2010 Jan; 73(1):1-6.
2009
Cheng J, Yang Y, Ma J, Wang W, Liu X, Sakamoto M, Qu Y, Shi W. Assessing noxious effects of dietary exposure to methylmercury, PCBs and Se coexisting in environmentally contaminated rice in male mice. Environ Int. (IF=13.352). 2009 Apr; 35(3):619-25.
Cheng J, Gao L, Zhao W, Liu X, Sakamoto M, Wang W. Mercury levels in fisherman and their household members in Zhoushan, China: impact of public health. Sci Total Environ. (IF=7.963) 2009 Apr 1;407(8):2625-30.
2008
Sakamoto M, Kubota M, Murata K, Nakai K, Sonoda I, Satoh H. Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population. Environ Res. (IF=8.431). 2008 Feb;106(2):270-6.
Liu X, Cheng J, Song Y, Honda S, Wang L, Liu Z, Sakamoto M, Liu Y. Mercury concentration in hair samples from Chinese people in coastal cities. J Environ Sci (China). 2008;20(10):1258-62.
Carratù MR, Coluccia A, Modafferi AM, Borracci P, Scaccianoce S, Sakamoto M, Cuomo V. Prenatal methylmercury exposure: effects on stress response during active learning. Bull Environ Contam Toxicol. (IF=2.151) 2008 Dec;81(6): 539-42.
Li P, Feng X, Qiu G, Li Z, Fu X, Sakamoto M, Liu X, Wang D. Mercury exposures and symptoms in smelting workers of artisanal mercury mines in Wuchuan, Guizhou, China. Environ Res. (IF=8.431) 2008;107(1):108-14.
2007
Iwata T, Sakamoto M, Feng X, Yoshida M, Liu XJ, Dakeishi M, Li P, Qiu G, Jiang H, Nakamura M, Murata K. Effects of mercury vapor exposure on neuromotor function in Chinese miners and smelters. Int Arch Occup Environ Health (IF=3.015) 2007 Apr; 80(5):381-7.
Ohno T, Sakamoto M, Kurosawa T, Dakeishi M, Iwata T, Murata K. Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function. Environ Res. (IF=8.431) 2007 Feb;103(2):191-7.
Mergler D, Anderson A H, Chan LHM, Mahaffey KR., Murray M, Sakamoto M, Stern A H. Methylmercury Exposure and Health Effects in Humans: A Worldwide Concern. The Panel on Health Risks and Toxicological Effects of Methylmercury: AMBIO (IF=3.616) 2007 Feb;36(1):3-11.
Sakamoto M, Feng X, Li O, Qiu G, Jiang H, Yoshida M, Iwata T, Liu XJ, Murata K. High exposure of Chinese mercury mine workers to elemental mercury vapor and increased methylmercury levels in their hair. Environ Health Prev Med. (IF=3.674) 2007;12(2):66-70.
Sakamoto M, Kaneoka T, Murata K, Nakai K, Satoh H, Akagi H. Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population. Environ Res. (IF=8.431) 2007;103(1):106-11.
2006
Honda S, Hylander L, Sakamoto M. Recent advances in evaluation of health effects on mercury with special reference to methylmercury-A Minireview. Environ Health Prev Med. (IF=3.674) 2006 Jul;11(4):171-6.
Vu Duc Loi, Le Lan Anh, Trinh Anh Duc, Trinh Xuan Gian, Pham Gia Mon, Tran Van Huy, Nguyen Quoc Thong, Alian Boudou, Sakamoto M, Dao Van Bay. Contamination by cadmium and mercury of the water, sediment and biological component of hydrosystems around Hanoi. J Chemistry 2006; 44:382-386.
Murata K, Sakamoto M, Nakai K, Dakeishi M, Iwata T, Liu XJ, et al. Subclinical effects of prenatal methylmercury exposure on cardiac autonomic function in Japanese children. Int Arch Occup Environ Health (IF=3.015) 2006 Jan; 11(1):17-23.
Iwata T, Nakai K, Sakamoto M, Dakeishi M, Satoh H, Murata K. Factor affecting hand tremor and postural sway in children. Environ Health Prev Med. (IF=3.674) 2006 Jan;11(1):17-23.
2005
Sakamoto M, Yasutake A, Satoh H. Methylmercury exposure in general populations of Japan, Asia and Oceania. Dynamics of mercury pollution on regional and global scales: atmospheric processes and human exposures around the world. N. Pirrone & K.R. Mahaffey (Eds) Springer 2005 p125-146.
Sakamoto M, Murata K, Nakai K, Satoh H. Difference in methylmercury exposure to fetus and breast-feeding offspring: a mini-review. Kor J Env Hlth. 2005; 31:179-186.
Pan HS, Sakamoto M, Liu XJ, Futatsuka M. Deficits in rat brain growth induced by methylmercury treatment during the brain growth spurt. J Health Sci. 2005 51(1):1-7.
Dakeishi M, Nakai K, Sakamoto M, Iwata T, Suzuki K, Liu X, et al. Effects of hair treatment on hair mercury - The best biomarker of methylmercury exposure? Environ Health Prev Med. (IF=3.674) 2005 Jul;10(4):208-12.
2004
Sakamoto M, Kubota M, Liu XJ, Murata K, Nakai K, Satoh H. Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus. Environ Sci Technol. (IF=11.357) 2004;38:3860-3863.
Sakamoto M, Kakita A, Oliveira RB, Pan HS, Takahashi H. Dose-dependent effects of methylmercury administered during neonatal brain spurt in rats. Dev Brain Res (IF=2.746) 2004;152:171-176.
Murata K, Sakamoto M, Nakai K, Weihe P, Dakeishi M, Iwata T, Liu XJ, Ohno T, Kamiya K, Satoh H. Effects of methylmercury on neurodevelopment in Japanese children in relation to Madeiran study. Int Arch Occup Environ Health (IF=3.015) 2004;77:571-579.
Sakamoto M, Kubota M, Liu XJ, Murata K, Nakai K, Satoh H. Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus. Environ Sci Technol. (IF=11.357) 2004;38:3860-3863.
Nakai K, Suzuki K, Oka T, Murata K, Sakamoto M, Okamura K, Hosokawa T, Sakai T, Nakamura T, Saitoh Y, Kurokawa N, Kameo S, Satoh H. A Cohort study of effects of perinatal exposures to methylmercury and environmentally persistent organic pollutants on neurobehavioral development in Japanese children. Tohoku J Exp Med. (IF=1.423) 2004;202:227-237.
Pan HS, Sakamoto M, Oliveira RB, Liu XJ, Kakita A, Futatsuka M. Changes in methylmercury accumulation in the brain of rat offspring throughout gestation and during suckling. Toxicol Environ Chem. (IF=0.972) 2004;86:163-170.
Sakamoto M, Kubota M. Plasma fatty acid profiles in 38 pairs of maternal and umbilical cord blood samples. Environ Health Prev Med. (IF=3.674) 2004 Mar;9(2):67-9.
2003
Iwasaki Y, Sakamoto M, Nakai K, Oka T, Deshimaru M, Iwata T, Satoh H, Murata K. Estimation of daily mercury intake from seafood in Japanese women: Akita Cross-Sectional Study. Tohoku J Exp Med (IF=1.423) 2003; 200:67-73.
Kakita A, Inenaga C, Sakamoto M, Takahashi H. Disruption of postnatal progenitor migration and consequent abnormal pattern of glial distribution in the cerebral cortex following administration of methylmercury. J Neuropathol Exp Neurol. (IF=3.490) 2003;62(8):835-847.
Kakita A, Inenaga C, Sakamoto M, Takahashi H. Neuronal migration disturbance and consequent cyoarchitecture in the cerebral cortex following transplacental administration of methylmercury. Acta Neuropathol. (IF=17.088) 2003;104(4):409-417.
Sakamoto M, Kubota M, Matsumoto S, Nakano A, Akagi H. Declining risk of methylmercury exposure to infants during lactation. Environ Res. (IF=8.431) 2003:90 (3):185-189.
2002
Kakita A, Inenaga C, Sakamoto M, Takahashi H. Neuronal migration disturbance and consequent cytoarchitecture in the cerebral cortex following transplacental administration of methylmercury. Acta Neuropathol. (IF=15.872) 2002;104:409-417.
Sakamoto M, Kakita A, Wakabayashi K, Takahashi H, Nakano A, Akagi H. Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods. Brain Res. (IF=3.125) 2002;949:51-59.
2001
Sakamoto M, Nakano A, Akagi H. Declining. Minamata male birth ratio associated with increased male fetal death due to heavy methylmercury pollution. Environ Res. (IF=8.431) Section A 2001;87:92-98.
Kakita A, Wakabayashi K, Su M, Sakamoto M, Ikuta F, Takahashi H. Intrauterine methylmercury intoxication: pattern of neuronal degeneration in the fetal brain and consequence on higher brain function in maturity. In: Takizawa Y and Osame M (eds.), Understanding of Minamata Disease. Methylmercury Poisoning in Minamata and Niigata, Japan. The Japan Public Health Association, Tokyo, 2001. pp.85-93.
2000
Kakita A, Wakabayashi K, Su M, Sakamoto M, Ikuta F, Takahashi H. Distinct pattern of neuronal degeneration in the fetal rat brain induced by consecutive transplacental administration of methylmercury. Brain Res. (IF=3.252) 2000;859:233-239.
Kakita A, Wakabayashi K, Su M, Yoneoka Y, Sakamoto M, Ikuta F, Takahashi H. Intrauterine methylmecury intoxication Consequence of the inherent brain lesions and cognitive dysfunction in maturity. Brain Res. (IF=3.252) 2000; 877:322-330.
1999
Fukuda Y, Ushijima K, Kitano T, Sakamoto M, Futatsuka M. An analysis of subjective complaints in a population living in a methylmercury-polluted area. Environ Res. (IF=8.431) Section A 1999;81:100-107.
1998
Oyama Y, Nakata M, Sakamoto M, Chikahisa L, Miyoshi N, Satoh M. Methylmercury toxicity in dissociated rat brain neurons: modification by L-cysteine and trimethylbenzylmercaptan and comparison with dimethylmercury and N-ethylmaleimide. Environ Toxicol & Pharmacol. (IF=2.776) 1998;6:221-227.
Sakamoto M, Wakabayashi K, Kakita A, Takahashi H, Adachi T, Nakano A. Widespread neuronal degeneration in rats following oral administration of methylmercury during the postnatal developing phase: a model of fetal-type Minamata Disease. Brain Res. (IF=3.252) 1998;784:351-354.
1997
Okazaki E, Oyama Y, Chikahisa L, Nagano T, Katayama N, Sakamoto M. Fluorescent estimation on cytotoxicity of methylmercury in dissociated cerebellar neurons: its comparison with ionomycin. Environ Toxicol & Pharmacol. (IF=2.776) 1997;3:237.
1996
Sakamoto M, Ikegami N, Nakano A. Protective Effects of Ca2+ Channel Blockers against Methyl Mercury Toxicity. Pharmacol & Toxicol. (IF=2.659) 1996;78:193-199.
1995
Wakabayashi K, Kakita A, Sakamoto M, Su M, Iwanaga K, Ikuta F. Variability of brain lesions in rats administered methylmercury at various postnatal development phases. Brain Res. (IF=3.252) 1995;705:267-272.
Sakamoto M, Nakano A. Comparison of mercury accumulation among the brain, liver, kidney, and the brain regions of rats administered methylmercury in Various Phases of Postnatal Development. Bull Environ Contam Toxicol (IF=2.151) 1995;55:588-596.
1993
Kinjo Y, Higashi H, Nakano A, Sakamoto M, Sakai R. Profile of Subjective Complaints and Activities of Daily Living among Current Patients with Minamata Disease after 3 Decades. Environ Res. (IF=8.431) 1993;63:241-251.
Sakamoto M, Nakano A, Kajiwara Y, Naruse I, Fujisaki T. Effects of methyl mercury in postnatal developing rats. Environ Res. (IF=8.431) 1993;61:43-50.
1991
Kinjo Y, Nakano A, Sakamoto M, Futatsuka M, Kato H. Clarification of mortality patterns among Minamata Disease patients. Environ Sci 1991;1(2):73-88.
Sakamoto M, Nakano A, Kinjo Y, Higashi H, Futatsuka M. Present mercury levels in red blood cells of nearby inhabitants about 30 years after the outbreak of Minamata Disease. Ecotox Environ Safety (IF=7.179), 1991;22:58-66.
1990
Wakisaka I, Yanagihashi T, Nakano A, Sakamoto M. Interaction of sulfur dioxide and nicotine aerosol as sensory irritants. Acta Med Univ Kagoshima 1990;42(1): 59-67.
Nakamura K, Sakamoto M, Uchiyama H, Yagi O. Organomercurial-volatilizing bacteria in the mercury-polluted sediment of Minamata Bay, Japan. Appl & Environ Microbiology (IF=4.792) 1990;56(1):304-305.
1987
Ando T, Sakamoto M, Yanagihashi T. Effect of methylmercury on the lipid components in rats. Acta Med Univ Kagoshima 1987;29(2):67-74.
1985
Kanazawa A, Teshima S, Sakamoto M. Effect of dietary lipids, fatty acids, and phospholipids on growth and survival of prawn (penaeus japonicus) larvae. Aquaculture (IF=4.242)1985; 50:39-49.
Sakamoto M. Effect of methylmercury on the lipid composition in guinea pigs. Industrial Health 1985, 23, 171-179.
1982
Sakamoto M, Holland DL, Jones DA. Modification of the nutritional composition of Artemia by incorporation of polyunsaturated fatty acids using micro-encapsulated diets. Aquaculture (IF=4.242) 1982; 28:311-320.
Kanazawa A, Teshima S, Sakamoto M. Requirements of essential fatty acids for the larval Ayu. Bull Jap Soc Sci Fisheries 1982;48(4):587-590.
Teshima S, Kanazawa A, Sakamoto M. Essential fatty acids of Tilapia nilotica. Mem. Fac. Fish., Kagoshima Univ 1982;31:201-204.
1980
Kanazawa A, Teshima S, Sakamoto M, Shinomiya A. Nutritional requirements of the puffer fish: purified test diet and the optimum protein level. Bull Jap Soc Sci Fisheries 1980;40(11):1957-1961.
Kanazawa A, Teshima S, Sakamoto M, Md. Awal A. Requirements of Tilapia zillii for essential fatty acids. Bull Jap Soc Sci Fisheries 1980;40(11):1353-1356.
Japanese: Original articles and authored books
2020
Sakamoto M, Kakita A, Nakamura M. "Methylmercury" -Brain development and its abnormalities- D. Abnormalities due to external factors. CLINICAL NEUROSCIENCE (In Japanese) 2020 Dec; 38(12): 1594-1597.
2018
Ueda Y, Hagiwara T, Sakamoto M, Minami T. Dimercaptosuccinic acid inhibits reduction in ciliary movements of third ventricular ependymal cells induced by methylmercury administration in mice. BIOMEDICAL RESEARCH ON TRACE ELEMENTS (In Japanese) 2018; 29(2/3): 119-131.
Sakamoto M, Nakamura M, Murata K. Mercury as a Global Pollutant and Mercury Exposure Assessment and Health Effects. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine), 2018; 73(3): 258-264.
2017
Saito M, Sakamoto M. Minamata Convention on Mercury. Health risks due to environmental factors I: Fundamentals of environmental issues. Nihon Ishikai Zasshi (The Journal of the Japan Medical Association) 2017; 146 Special Issue (2): 67-70.
Sakamoto M, Murata K. Minamata disease. Health risks due to environmental factors IV: A case study of health hazards due to environmental pollutions. Nihon Ishikai Zasshi (The Journal of the Japan Medical Association) 2017; 146 Special Issue (2): 296-299.
Sakamoto M, Itai T, Murata K. Effects of Prenatal Methylmercury Exposure: From Minamata Disease to Environmental Health Studies. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine) 2017; 72(3): 170-148.
2016
Karita K, Sakamoto M, Yoshida M, Tatsuta N, Nakai K, Iwai M, Iwata T, Maeda E, Yaginuma K, Sato H, Murata K. Recent Epidemiological Studies on Methylmercury, Mercury and Selenium. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine) 2016; 71: 236-251.
2014
Sakamoto M, Murata K. Chapter 2: Global mercury pollution and its effects on human health: Minamata Convention on Mercury and the latest countermeasures and technologies. Supervised by Takaoka M. CMC Publishing, 2014 Nov. pp15-22.
2013
Usuki F, Sakamoto M. Methylmercury toxicosis in fetuses. In: Neurological Syndromes (2nd ed.) IV -Including other neurological diseases-. Nippon Rinsho (The Japanese Journal of Clinical Medicine) 2014 09.819-822. Sakamoto M, Murata K. Toxicity of mercury -History of pollution and current status of research-. Kankyo Gijutsu (Environmental Conservation Engineering) 2013 Oct; 42(10):584-589.
Sakamoto M, Yamamoto M. Trace elements in food: From essential elements to radioactive nuclides. Chapter 8: Mercury (methylmercury). Edited by Japan Food Hygiene Association (In Japanese). April 2013
2011
Sakamoto M, Yasutake A: Seafood and methylmercury. Modern Media (In Japanese) 57(3), 16-21, 2011.
2010
Sakamoto M, Yamamoto M: Trends in research on trace elements 3: Mercury (methylmercury). Shokuhin Eisei Kenkyu (Food Sanitation Research) 2010; 60(12):35-41.
Sakamoto M, Sasaki M. Methylmercury: Extensive hematology, urinalysis, and immunological testing (2) -How should we read the values?-, Nippon Rinsho (The Japanese Journal of Clinical Medicine) Vol. 68, Supplement, 2010; 1:576-580.
Sakamoto M: Methylmercury. Food Safety Handbook (In Japanese). Edited by Food Safety Commission of Japan. Maruzen. 2010. pp118-120.
Murata K, Sakamoto M, Sato H: Diversity of methylmercury exposure and health risk. Special Issue on Environmental Risk. Koushu Eisei (The Journal of Public Health Practice) 2010;74: 279-283.
2007
Liu X, Sakamoto M, Kato T, Okamoto M, Arimura K. A study on the current activity of daily living (ADL) of patients with fetal Minamata disease compared with 15 years ago and communication disorder in those patients. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine) 2007; 62(3):905-910.
2006
Sakamoto M, Akagi H. Inorganic and Organic Mercury (Water Environmental Handbook). Japan Society on Water Environment. Asakura Shoten. 2006. pp352-355 (In Japanese)
2005
Sakamoto M, Akagi H. Toxicity and health effects of mercury. Toxicity and Health Effects of Mercury. Haikibutsu Gakkaishi (Material Cycles and Waste Management Research) 2005; 6: 185-190.
2004
Sakamoto M, Eto M. Is trace amounts of methylmercury harmful to adults? Igaku No Ayumi (Journal of Clinical and Experimental Medicine) 2004; 211: 1155-1156.
Sakamoto M, Akagi H. Methylmercury (Extensive hematology, urinalysis, and immunological testing -How should we read the values?-) Nippon Rinsho (The Japanese Journal of Clinical Medicine) Vol. 62, Supplement, 2004; 12: 529-532.
1999
Sakamoto M. Industrial waste that crossed the sea - What I saw in Cambodia -. INDUST (In Japanese) 1999; 142:36-38.
1996
Sakamoto M, Nakano A, Akagi H. The significance of mercury concentration in red blood cells: From methylmercury contamination index to seafood intake index. FFI JOURNAL (In Japanese) 1996; 167: 109-115.
1992
Sakamoto M, Nakano A, Kinjo Y, Wakamiya J, Fujisaki T, Azuma H, Kitano T, Futatsuka M. Cross-sectional study of lipid peroxide levels (plasma TBA levels) in general population screening. Nihon Koushu Eisei Zasshi (Japanese Journal of Public Health) 1992; 39(7): 399-409.
1991
Kinjo Y, Nakano A, Sakamoto M, Watanabe M, Futatsuka M, Kato H. A follow-up study of the mortality structure of Minamata disease patients: Analysis by mortality rate and standardized mortality ratio (SMR). Hoken No Kagaku (Health Care) 1991; 33(8): 579-583.
1990
Sakamoto M, Nakano A, Kinjo Y, Higashi H, Futatsuka M. Relationship between complaints in general health screening and arteriosclerosis indexes. Minzoku Eisei (Japanese Journal of Health and Human Ecology) 1990;56(2):87-96.
Shimizu T, Higashi H, Takase C, Sakamoto M. Evaluation of body fat measurement by Fitness Analyzer BFT-2000. Hoken No Kagaku (Health Care) 1990;32(12):848-849.
1989
Ando T, Wakisaka I, Yanagihashi T, Sakamoto M. Methylmercury administration and lipid peroxidation in rats. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine) 1989;44(3):733-738.
Ando T, Yanagihashi T, Wakisaka I, Sakamoto M. Lipid peroxidation and fatty acid composition in rats exposed to methylmercury. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine) 1989;44(5):993-1001.
1988
Sakamoto M, Wakisaka I, Ando T, Yanagihashi T. Effect of dietary lipids on lipid peroxidation and mercury accumulation in rat tissues. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine) 1988;43(4):917-922.
Ando T, Wakisaka I, Yanagihashi T, Sakamoto M. Effect of ethanol on accumulation and excretion of mercury in rats. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine) 1988;43(4): 717-723.
1986
Sakamoto M. Effect of dietary lipids on methylmercury poisoning. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine) 1986;40(66):903-909.
1985
Sakamoto M. Ethane content in the breath of smokers and nonsmokers. Nihon Eiseigaku Zasshi (Environmental Health and Preventive Medicine) 1985;40(5):835-840.
1984
Wakisaka I, Yanagihashi T, Tomari T, Ando T, Sakamoto M. Effects of Sakurajima volcanic activity on the mortality profile. Nihon Koushu Eisei Zasshi (Japanese Journal of Public Health) 1984;31(10):548-556.
Externally-funded research(principal roles only)
FY2019-2022 JSPS Grant-in-Aid for Scientific Research (C) (Principal Investigator)
Selenium against methylmercury toxicity: A novel analysis using environmental and patient samples at the time of Minamata disease outbreak
FY2015-2018 JSPS Grant-in-Aid for Scientific Research (C) (Principal Investigator)
Mercury speciation in preserved sludge which is estimated to be remaining under the reclaimed land area of Minamata Bay Japan
FY2011-2013 JSPS Grant-in-Aid for Scientific Research (C) (Principal Investigator)
Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat brain
FY2006-2008 JSPS Grant-in-Aid for Scientific Research (C) (Principal Investigator)
Delayed effects of prenatal exposure to methylmercury on nervous system and physiological aging
Main career history, academic history, academic degrees, awards, etc.
Doctor of Medicine
Academic affiliations: Japanese Society for Hygiene, Japan Society for Biomedical Research on Trace Elements
2018-2020:Visiting Professor, Tohoku University Graduate School of Medicine
2017:The 29th Presidential Award of the National Personnel Authority (individual category)
2017-:Part-time Lecturer, Mie University Graduate School of Medicine and Faculty of Medicine
2017-:Part-time Lecturer, Kumamoto University Graduate School of Pharmaceutical Sciences
2017-:Visiting Research Fellow, Kagoshima University Graduate School of Medical and Dental Sciences
2014-2016:Visiting Professor, Federal University of Western Pará Brazil
2014-2019:Visiting Professor, Prefectural University of Kumamoto
2014-:Editorial Board Member: Environ Res
2013-:Visiting Associate Professor, Kumamoto University Graduate School of Medical Sciences
2007-2018:Executive Committee Member, International Conference on Mercury as a Global Pollutant
2005-2007:Editorial Board Member, Japanese Society for Hygiene