Our organization, departments, staff and researchers
Akio Sumioka
The research group I work for : Pathomechanism Group
Specialty: Neuroscience I conducted research on Alzheimer's disease at graduate school and then, during my study abroad at Yale University, molecular mechanisms that control memory and learning and, after coming back to Japan, again engaged in research of the pathogenesis of Alzheimer's disease, focusing on causal factors, at the National Center for Geriatrics and Gerontology and at Gakushuin University. My goal as a researcher is to bring to light molecular mechanisms behind physiological and pathological phenomena. At NIMD, I harness my past experience to approach the issue of the cellular specificity of toxicity from methylmercury.
Research theme - Areas of work
Basic Research
Research on the mechanism of the late stage of methylmercury neurotoxicity (Principal Investigator)
Main research achievements
Research papers
2016
J. Yoshitake, Y. Soeda, T. Ida, A. Sumioka, M. Yoshikawa, K. Matsushita, T.Akaike, and A. Takashima*. Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): Effects of nitric oxide-linked chemical modification on Tau aggregation. J Biol Chem, 291 (2016), 22714-22720. Peer-reviewed.
2015
Y. Soeda, M. Yoshikawa, O. F. Almeida, A. Sumioka, S. Maeda, H. Osada, Y.Kondoh, A. Saito, T. Miyasaka, T. Kimura, M. Suzuki, H. Koyama, Y. Yoshiike, H.Sugimoto, Y. Ihara, and A. Takashima*. Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nat Commun. 6 (2015), 10216. Peer-reviewed.
2011
A. Sumioka, T. E. Brown, A. S. Kato, D. S. Bredt, J. A. Kauer, and S. Tomita*, PDZ binding of TARPgamma-8 controls synaptic transmission but not synaptic plasticity, Nat Neurosci, 14 (2011), 1410-1412. Peer-reviewed. F1000-selected paper (13360064).
Y. Saito, M. Akiyama, Y. Araki, A. Sumioka, M. Shiono, H. Taru, T. Nakaya, T. Yamamoto, and T. Suzuki*, Intracellular trafficking of the amyloid beta-protein precursor (APP) regulated by novel function of X11-like, PLoS One, 6 (2011), e22108. Peer-reviewed.
2010
A. Sumioka, D. Yan, and S. Tomita*, TARP phosphorylation regulates synaptic AMPA receptors through lipid bilayers, Neuron, 66 (2010), 755-767. Peer-reviewed. F1000-selected paper (20547132).
2009
W. Zhang, F. St-Gelais, C. P. Grabner, J. C. Trinidad, A. Sumioka, M.Morimoto-Tomita, K. S. Kim, C. Straub, A. L. Burlingame, J. R. Howe, and S.Tomita*, A transmembrane accessory subunit that modulates kainate-type glutamate receptors, Neuron, 61 (2009), 385-396. Peer-reviewed.
2008
A. Sumioka, Y. Saito, M. Sakuma, Y. Araki, T. Yamamoto, and T. Suzuki*,The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm, Exp Cell Res, 314 (2008), 1155-1162. Peer-reviewed.
2005
A. Sumioka, S. Nagaishi, T. Yoshida, A. Lin, M. Miura, and T. Suzuki*, Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment, J Biol Chem, 280 (2005), 42364-42374.Peer-reviewed.
M. Asaumi, K. Iijima, A. Sumioka, K. Iijima-Ando, Y. Kirino, T. Nakaya, and T. Suzuki*, Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion, J Biochem, 137 (2005), 147-155. Peer-reviewed.
2004
A. Sumioka, M. Miura, and T. Suzuki*, 14-3-3 modulates gene transactivation of AICD through it's interaction between C-terminal region of APP, Neurobiology of Aging, 25 (2004), S176-S176. non peer-reviewed.
2003
Y. Araki, S. Tomita, H. Yamaguchi, N. Miyagi, A. Sumioka, Y. Kirino, and T.Suzuki*, Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism, J Biol Chem, 278 (2003), 49448-49458. Peer-reviewed.
A. Sumioka, S. Imoto, R. N. Martins, Y. Kirino, and T. Suzuki*, XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms, Biochem J, 374 (2003), 261-268. Peer-reviewed.
2002
M. Hase, Y. Yagi, H. Taru, S. Tomita, A. Sumioka, K. Hori, K. Miyamoto, T.Sasamura, M. Nakamura, K. Matsuno, and T. Suzuki*, Expression and characterization of the Drosophila X11-like/Mint protein during neural development,J Neurochem, 81 (2002), 1223-1232. Peer-reviewed.
A. Sumioka, H. Taru, S. Tomita, and T. Suzuki*, Characterization of X11-like binding protein, XB51, Neurobiology of Aging, 23 (2002), S195-S195. non peer-reviewed.
M. Hase, Y. Yagi, H. Taru, S. Tomita, A. Sumioka, K. Hori, K. Miyamoto, T.Sasamura, M. Nakamura, K. Matsuno, and T. Suzuki*, Expression and characterization of the Drosophila X11-like/Mint protein during neural development.J Neurochem 81 (2002) 1223-1232. Peer-reviewed.
Reviews
2013
A. Sumioka* Auxiliary Subunits Provide New Insights into Regulation of AMPA Receptor Traffiking. J. Biochem. 153 (2013), 331-337. Peer-reviewed.
Sumioka A*: Control of glutamate receptor functions by supporting subunits. Seikagaku (The Journal of Biochemistry, Vol. 85, April 2013, p. 275-278. Non peer-reviewed.
2009
Sumioka A: Tomita S*. Synaptic trafficking of lonotropic glutamate receptors. Saibo Kogaku (Cell Technology), No. 28, September 2009, p. 915-919.
2006
Sumioka A, Suzuki T: New signal information transmission by membrane proteins and adaptor molecules in nerve cells. Seikagaku (The Journal of Biochemistry), No. 78, October 2006, p. 949-956.
Authored books
Academic journal contributions
2007
Sumioka A: My study abroad at Yale University, Nihon Seirigaku Zasshi (Journal of Physiological Sciences), Vol. 69 No. 4, April 2007, p. 163-164.
Externally-funded research(principal roles only)
Competitive research funds
FY2015-2016 Ono Medical Research Foundation Research Grant
FY2014-2018 JSPS Grant-in-Aid for Early-Career Scientists (B)
FY2013-2015 The Tokyo Biochemical Research Foundation Research Grant
FY2012-2014 The Naito Foundation Research Grant
FY2012-2014 JSPS Grant-in-Aid for Research Activity Startup
FY2009-2011 JSPS Overseas Research Fellowship
FY2004-2006 JSPS Research Fellows (DC2)
Collaborative research with industry (Principal Investigator)
FY2017 Collaborative research with Funakoshi Co., Ltd.
FY2015-2017 Collaborative research with Ono Pharmaceutical Co., Ltd.
Main career history, academic history, academic degrees, awards, etc.
2018National Institute for Minamata Disease
2016-2018Research Associate, Takashima Laboratory, Department of Life Science, Faculty of Science, Gakushuin University
2012-2016Chief, Targeted Treatment Development Section, Department of Molecular Foundation Research, National Center for Geriatrics and Gerontology
2006-2012Post-Doctoral Fellow, Tomita Research Group on Cellular and Molecular Physiology, Yale University School of Medicine
2006Research Assistant, Suzuki Laboratory, Faculty of Pharmaceutical Sciences, Hokkaido University
2006Ph. D. in Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, University of Tokyo
