NAGANO Masaaki
Division (Section) name/title:Department of Basic Medical Science (Hygienic Chemistry Section) / Senior Researcher
Degree(s):Doctor of Pharmacology
Academic Specialty Field:Pharmacy, Pharmaceutical health science
Environmental Specialty Field:Environmental toxicology
Research Subject(FY 2012-)
  • FY 2015-:Study on the modifying factors to methylmercury toxicity (representative)
  • FY 2015-:Fundamental research on prevention and treatment of methylmercury toxicity (collaborator)
  • FY 2015-:Study on risk governance of health effect of methylmercury (collaborator)
  • FY 2012-2014:Research on effect of dietary fibers on mercury excretion after MeHg exposure (representative)
  • FY 2013-2014:Study of information and perception of the health risk of low-level exposures to methylmercury (collaborator)
  • FY 2013:Research on the relation between methylmercury levels and marine bacteria in the water of Minamata Bay (representative)
  • FY 2012-2014:Research on its influences and behaviors of mercury in an aquatic environment of Minamata Bay (collaborator)
  • FY 2013-2014:Mercury contamination by many small-scale gold ore smelters in Talawaan River, North Sulawesi, Indonesia (collaborator)
  • FY 2012:Marine ecosystem and mercury behavior in Yatsushiro Sea. -Quantitative survey of marine benthic community in Yatsushiro Sea and mercury concentration of several fishes through food web- (collaborator)
  • FY 2012-:Information service using hair Hg analysis (representative)
Research Result (Publication)
  [Original article]
  • Adachi T, Nagano M: Influence of dietary protein levels on the acute toxicity of inorganic mercury in mice., J. Health Sci., 57, 362-366 (2011)
  • Nagano M, Yasutake A, Miura K: Demethylation of methylmercury in human neuroblastoma, glioblastoma and liver cells., J. Health Sci., 56, 326-330 (2010)
  • Shimada H, Narumi R, Nagano M, Yasutake A, Wallkes MP, Imamura Y: Strain difference of cadmium-induced testicular toxicity in inbred Wister-Imamichi and Fisher 344 rats. Arch. Toxicol., 83, 647-652 (2009)
  • Adachi T, Nagano M, Ebihara T, Imai T, Fujimura M, Suketa Y: Influence of dietary protein levels on the fate of inorganic mercury in mice. J. Health Sci., 54, 207-211 (2008)
  • Shimada H, Nagano M, Funakoshi T, Imamura Y: Effects of chelating agents on distribution and excretion of terbium in mice., Toxicol. Mech. Methods, 15, 181-184 (2005)
  • Yasutake A, Nagano M, Nakano A: Simple method for methylmercury estimation in biological samples using atomic absorption spectroscopy., 51, 220-223 (2005)

  [Past Publication (prior to and including FY 2004)]
  • Yamaguchi M, Yasutake A, Nagano M, Yasuda Y: Accumulation and distribution of methylmercury in freshwater- and seawater-adapted eels., Bull. Environ. Contam. Toxicol., 73, 257-263 (2004)
  • Yasutake A, Nagano M, Hirayama K: Alterations of metallothionein isomers in Hg(0)-exposed rat brain. Arch. Toxicol., 77, 12-16 (2003)
  • Shimada H, Nagano M, Yasutake A, Imammura Y: Wistar-Imamichi rats exhibit a strong resistance to cadmium toxicity., J. Health Sci., 48, 201-203 (2002)
  • Nagano M, Shimada H, Funakoshi T, Yasutake A: Increase of calcium concentration in the testes of mice treated with rare earth metals. J. Health Sci., 46, 314-316 (2000)
  • Yoshikawa I, Takatsuji T, Nagano M, Takada J, Endo S, Hoshi M: RBE-LET relationships of high-LET radiations in Drosophila Mutations. J. Radiat. Res., 40, 106-116 (1999).
  • Nagano M, Takatsuji T, Yoshikawa I, Endo S, Takada J, Hoshi M: Effect of gravity on the induction of somatic mutations by radiation in Drosophila, Biol. Sci. Space, 12, 192-193 (1998)
  • Ohsako M, Sakurai M, Suetomi J, Nagano M, Soeda T, Ichikawa M, Tsuzuki O: Transport of 5-Fluorouracil and its derivatives through human erythrocyte membrane. J. Pharm. Sci. Technol., Jpn., 58, 171-178 (1998).
  • Nagano M, Shimada H, Funakoshi T, Kojima S: Effect of terbium chloride on secretion of pulmonary surfactant in mice. Res. Comm. Pharmacol. Toxicol., 2, 23-32 (1997)
  • Kojima S, Fukuda T,Nagano M, Shimada H, Funakoshi T: Effects of rare earth metals on small intestinal absorption of L-histidine and L-leucine in mice. Res. Comm. Pharmacol. Toxicol., 2, 13-22 (1997)
  • Shimada H, Nagano M, Funakoshi T, Kojima S: Pulmonary toxicity of systemic terbium chloride in mice. J. Toxicol. Environ Health, 48, 81-92 (1996)
  • Sakurai M, Ohsako M, Nagano M, Nakamura C, Tsuzuki O, Ichikawa M, Matsumoto Y: Effect of human serum albumin on transport of drugs through human erythrocyte membranes., Yakugaku Zasshi, 116(8), 630-638 (1996)

  • Yoshikawa I, Takatsuji T, Nagano M, Hoshi M, Takada J, Endo S: The induction of somatic mutations by high-LET radiation observed using the drosophila assay system., In: Risk Evaluation of Cosmic-Ray Exposure in Long-Term Manned Space Mission, Eds. Fujitaka K, Majima H, Ando K, Yasuda H, Suzuki M., pp. 89-99, Kodansha Scientific, Tokyo.