Akio Sumioka Ph.D.
Senior Researcher, Hygienic Chemistry Section, Basic Medical Sciences
Specialty: Neuroscience
Subjects of study and affair
Basic Research
Research on the mechanism of the late stage of methylmercury neurotoxicity (Representative)

Gene recombination experiment safety committee
Crating public relations magazine Committee
Study groups
Research achievements
  1. J. Yoshitake, Y. Soeda, T. Ida, A. Sumioka, M. Yoshikawa, K. Matsushita, T. Akaike, and A. Takashima*. Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): Effects of nitric oxide-linked chemical modification on Tau aggregation. J Biol Chem, 291 (2016), 22714-22720.
  2. Y. Soeda, M. Yoshikawa, O. F. Almeida, A. Sumioka, S. Maeda, H. Osada, Y. Kondoh, A. Saito, T. Miyasaka, T. Kimura, M. Suzuki, H. Koyama, Y. Yoshiike, H. Sugimoto, Y. Ihara, and A. Takashima*. Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nat Commun. 6 (2015), 10216.
  3. A. Sumioka, T. E. Brown, A. S. Kato, D. S. Bredt, J. A. Kauer, and S. Tomita*, PDZ binding of TARPgamma-8 controls synaptic transmission but not synaptic plasticity, Nat Neurosci, 14 (2011), 1410-1412. F1000 (13360064)
  4. Y. Saito, M. Akiyama, Y. Araki, A. Sumioka, M. Shiono, H. Taru, T. Nakaya, T. Yamamoto, and T. Suzuki*, Intracellular trafficking of the amyloid beta-protein precursor (APP) regulated by novel function of X11-like, PLoS One, 6 (2011), e22108.
  5. A. Sumioka, D. Yan, and S. Tomita*, TARP phosphorylation regulates synaptic AMPA receptors through lipid bilayers, Neuron, 66 (2010), 755-767. F1000 (20547132)
  6. W. Zhang, F. St-Gelais, C. P. Grabner, J. C. Trinidad, A. Sumioka, M. Morimoto-Tomita, K. S. Kim, C. Straub, A. L. Burlingame, J. R. Howe, and S. Tomita*, A transmembrane accessory subunit that modulates kainate-type glutamate receptors, Neuron, 61 (2009), 385-396.
  7. A. Sumioka, Y. Saito, M. Sakuma, Y. Araki, T. Yamamoto, and T. Suzuki*, The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm, Exp Cell Res, 314 (2008), 1155-1162.
  8. A. Sumioka, S. Nagaishi, T. Yoshida, A. Lin, M. Miura, and T. Suzuki*, Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment, J Biol Chem, 280 (2005), 42364-42374.
  9. M. Asaumi, K. Iijima, A. Sumioka, K. Iijima-Ando, Y. Kirino, T. Nakaya, and T.Suzuki*, Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion, J Biochem, 137 (2005), 147-155.
  10. A. Sumioka, M. Miura, and T. Suzuki*, 14-3-3 modulates gene transactivation of AICD through its interaction between C-terminal region of APP, Neurobiology of Aging, 25 (2004), S176-S176.
  11. Y. Araki, S. Tomita, H. Yamaguchi, N. Miyagi, A. Sumioka, Y. Kirino, and T. Suzuki*,Novelcadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism, J Biol Chem, 278 (2003), 49448-49458.
  12. A. Sumioka, S. Imoto, R. N. Martins, Y. Kirino, and T. Suzuki*, XB51 isoformsmediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms, Biochem J, 374 (2003), 261-268.
  13. M. Hase, Y. Yagi, H. Taru, S. Tomita, A. Sumioka, K. Hori, K. Miyamoto, T. Sasamura, M. Nakamura, K. Matsuno, and T. Suzuki*, Expression and characterization of the Drosophila X11-like/Mint protein during neural development, J Neurochem, 81 (2002), 1223-1232.
  14. A. Sumioka, H. Taru, S. Tomita, and T. Suzuki*, Characterization of X11-like binding protein, XB51, Neurobiology of Aging, 23 (2002), S195-S195. 査読無
  15. M. Hase, Y. Yagi, H. Taru, S. Tomita, A. Sumioka, K. Hori, K. Miyamoto, T. Sasamura, M. Nakamura, K. Matsuno, and T. Suzuki*, Expression and characterization of the Drosophila X11-like/Mint protein during neural development. J Neurochem 81 (2002) 1223-1232.

    Review (English text)
  16. A. Sumioka* Auxiliary Subunits Provide New Insights into Regulation of AMPAReceptor Traffiking. J. Biochem. 153 (2013), 331-337.
Receptor Traffiking. J. Biochem. 153 (2013), 331-337.
Researches by the external funds
Competitive research fund (representative)
JSPS research fellowship for young scientist (DC2) 2004-2006
JSPS overseas research fellowship 2009-2011
JSPS grants-in-aid for research activity startup 2012-2014
The Naito foundation research grant 2012-2014
JSPS grants-in-aid for young scientists (B) 2012-2014
The Tokyo biochemical research foundation research grant 2013-2015
Ono medical research foundation research grant 2015-2016

Collaborative research with company (representative)
Ono pharmaceutical corporation 2015-2017
Funakoshi corporation 2017
The main history, academic background, degree, and citation etc.
2006 The university of Tokyo, graduate school of pharmaceutical sciences, Ph.D.
2006 Hokkaido university, faculty of pharmaceutical sciences, research assistant
2006-2012 Yale university, school of medicine, post-doctoral fellow
2012-2016 National center of geriatric and gerontology, section chief.
2016-2018 Gakushuin university, faculty of science, research associate
2018-present National institute for Minamata disease