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Takamitsu UNOKI, Ph.D.
Senior Researcher, Hygienic Chemistry Section, Department of Basic Medical Sciences
Research Subject
Basic Research
    Research on Selective Cytotoxicity of Methylmercury Focusing on Sulfur Nucleophiles (Principal Investigator)
Research Group
Pathomechanism Group
Publication
[Original Article]
  • Akiyama, M., Unoki, T., Shinkai, Y., Ishii, I., Ida, T., Akaike, T., Yamamoto, M., Kumagai, Y. (2019). Environmental electrophile-mediated toxicity in mice lacking Nrf2, CSE, or both. Environ. Health Perspect. 127, 67002.
  • Akiyama, M., Shinkai, Y., Unoki, T., Shim, I., Ishii, I., and Kumagai, Y. (2017). The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity. Chem. Res. Toxicol. 30, 2209-2217.
  • Abiko, Y., Shinkai, Y., Unoki, T., Hirose, R., Uehara, T., and Kumagai, Y. (2017). Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts. Sci. Rep. 7, 4814.
  • Abiko, Y., Sha, L., Shinkai, Y., Unoki, T., Luong, N.C., Tsuchiya, Y., Watanabe, Y., Hirose, R., Akaike, T., and Kumagai, Y. (2017). 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides. Free Radic. Biol. Med. 104, 118-128.
  • Unoki, T., Abiko, Y., Toyama, T., Uehara, T., Tsuboi, K., Nishida, M., Kaji, T., and Kumagai, Y. (2016). Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells. Sci. Rep. 6, 28944.
  • Hasegawa, H., Noguchi, J., Yamashita, M., Okada, R., Sugimoto, R., Furuya, M., Unoki, T., Funakoshi, Y., Baba, T., and Kanaho, Y. (2012). Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis. Biol. Reprod. 86, 136, 131-112.
  • Unoki, T., Matsuda, S., Kakegawa, W., Van, N.T., Kohda, K., Suzuki, A., Funakoshi, Y., Hasegawa, H., Yuzaki, M., and Kanaho, Y. (2012). NMDA receptor-mediated PIP5K activation to produce PI(4,5)P2 is essential for AMPA receptor endocytosis during LTD. Neuron 73, 135-148. F1000Prime Recommended
  • Nakano-Kobayashi, A., Yamazaki, M., Unoki, T., Hongu, T., Murata, C., Taguchi, R., Katada, T., Frohman, M.A., Yokozeki, T., and Kanaho, Y. (2007). Role of activation of PIP5Kγ661 by AP-2 complex in synaptic vesicle endocytosis. EMBO J. 26, 1105-1116.
[Reviews]
  • Kumagai, Y., Akiyama, M., Unoki, T. (2019). Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules. Toxicol. Res. 35, 303-310.
  • Unoki, T., Akiyama, M., Kumagai, Y., Gonçalves, F.M., Farina, M., da Rocha, J.B.T., Aschner, M. (2018). Molecular pathways associated with methylmercury-induced Nrf2 modulation. Front. Genet. 9, 373.
  • Kanaho, Y., and Unoki, T. (2012). Regulation and functions of the lipid kinase PIP5Kγ661 at synapses. Adv. Enzyme Regul. 52, 59-65.
Grant
2019-2020 Grant-in-Aid for Young Scientists, JSPS KAKENHI
Grant Number JP19K16368 (Principal Investigator)
2016-2017 Grant-in-Aid for Young Scientists (B), JSPS KAKENHI
Grant Number JP16K18920 (Principal Investigator)
Resume
2012 Ph.D. in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
2012-2014 Research Fellow, Faculty of Medicine, University of Tsukuba
2014-2018 Assistant Professor, Faculty of Medicine, University of Tsukuba
2018- Senior Researcher, Department of Basic Medical Sciences, National Institute for Minamata Disease