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| TOP > REPORT FROM INSTITUTE > RESEARCH ON THE EFFECT OF METHYLMERCURY ON CELLULAR SYSTEMS, LEADING
TO THE SOLUTION OF CLINICAL PROBLEMS |
| 3. Research on the effect of methylmercury on cellular systems, leading
to the solution of clinical problems |
This research project is aimed at elucidating the effect of methylmercury
(MeHg) on cellular systems and the molecular mechanisms of MeHg-intoxication.
The results will be developed to grasp of early toxic states, assessment
of MeHg-intoxication, and superior methods of the protection against MeHg-intoxication
and repair of damage attacked by MeHg. To achieve the objectives, in vitro
and in vivo studies are conducted, which include the change in cellular
signaling pathways and stress response by exposure to MeHg, the search
for biomarkers reflecting MeHg exposure, gene profiling analyses, the mechanism
of intracellular demethylation of MeHg, and the effect of MeHg on cell
differentiation and neural regeneration. Drugs will be tried for the block
of MeHg-intoxication and the promotion of neural regeneration.
1. Search for biomarkers for the Minamata Disease
2. Study on the molecules related to the process of methylmercury-intoxication
and their clinical application
3. In vivo study on the molecular mechanism and treatment of methylmercury-intoxication
4. Biological effects of methylmercury exposure of environmental level
5. Study on biotransformation and elimination of methylmercury in cultured
cells
6. Study for the effect of methylmercury on neuronal regeneration (proliferation
and extension) and its medical treatment
7. Studies on the treatment for methylmercury intoxication
8. Embryotoxicity screening of environmental toxicants using monkey embryonic
stem cells
9. Metallothionein dynamic study by mercury exposure
10.Dopaminergic toxicity in fetal mice exposed to methylmercury
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Rat cerebrocortical neuron |
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Profiling of protein of the cerebrospinal fluid in a model rat intoxicated
methylmercury |
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