トップ　＞　組織の案内　＞　環境・保健研究部
部長： 山元　恵（やまもと　めぐみ）(Mr.)　

　水銀化合物の曝露に伴う健康影響には個人差が見られます。メチル水銀曝露に対するハイリスクグループとして、高濃度の水銀に曝露したグループ、及び水銀に対する高感受性のグループが挙げられます。特に、胎児、乳幼児は、脳神経系が発達段階にあるため、メチル水銀に対する感受性が高いことが知られています。また、疾患に伴う代謝異常は水銀化合物の曝露に対する感受性に影響を及ぼす可能性があるため、これらのグループにおいてはメチル水銀への曝露を正確に把握し、健康影響に関する適切なリスク評価を行う必要があると考えられます。
　本研究室では、メチル水銀曝露に対するハイリスクグループにおける曝露評価研究、および感受性要因の解明を目指した実験研究を行っています。

主な研究テーマ・担当業務
所属研究グループ 
リスク評価グループ。国際・情報グループ
最近の主な研究業績
2010
  • Adler, R., Barbosa, F., Domingo, J., Flegal, R., Gardner, R., Goldman, L., Nyland, J., Sakamoto, M., Silbergeld, E., Stern, A., Wells, E., Yamamoto, M. “Children’s exposure to mercury compounds”. (2010) World Health Organization,
    Geneva. http://whqlibdoc.who.int/publications/2010/9789241500456_eng.pdf
  • Miyamoto, K., Kuwana, T., Ando, T., Yamamoto. M., Nakano, A. Methylmercury Analyses in Biological Materials by Heating Vaporization Atomic Absorption Spectrometry. J. Toxicol. Sci. (2010) vol35,217-224.
    https://www.jstage.jst.go.jp/article/jts/35/2/35_2_217/_pdf
  • Ando, T., Yamamoto, M., Tomiyasu, T., Tsuji, M., Akiba, S. Mercury distribution in seawater of Kagoshima Bay near the active volcano, Mt. Sakurajima in Japan.
    Bull. Environ. Contam. Toxicol. (2010) Apr;84(4):477-481.
2012
  • Yamamoto, M., Takeya, M., Ikeshima-Kataoka, H., Yasui, M., Kawasaki, Y., Shiraishi, M., Majima, E., Shiraishi, S., Uezono, Y., Sasaki, M., Eto, K. Increased expression of aquaporin-4 by methylmercury in the brain of Common Marmoset. J. Toxicol. Sci. (2012) 37:749-
    763. https://www.jstage.jst.go.jp/article/jts/37/4/37_749/_pdf
  • Mori, N., Yamamoto, M., Tsukada, E., Yokooji, T., Matsumura, N., Sasaki, M., Murakami, T. Comparison of in vivo with in vitro pharmacokinetics of mercury between methylmercury chloride and methylmercury cysteine using rats and Caco2 cells. Arch. Environ. Contam. Toxicol. (2012) Nov;63(4):628-636.
2013
  • Sakamoto, M., Yasutake, A., Kakita, A., Ryufuku, M., Chan, H. M., Yamamoto, M., Oumi, S., Kobayashi, S., Watanabe, C. Selenomethionine Protects against Neuronal Degeneration by Methylmercury in the Developing Rat Cerebrum. Environ. Sci. Technol. (2013) Mar 19;47(6):2862-2868.
  • Yamazaki, T., Yamamoto, M., Ishihara, Y., Komatsu, S., Munetsuna, E., Onizaki, M., Ishida, A., Kawato, S., Mukuda, T. De Novo synthesized estradiol protects against methylmercury-induced neurotoxicity in cultured rat hippocampal slices. PLoS One. (2013) 8(2):e55559.
  • 坂本峰至、山元　恵　「水銀（メチル水銀）」　食品中の微量元素―必須元素から放射能核種まで―. 日本食品衛生協会　2013年4月pp97-107.
2014
  • Yamamoto, M., Yanagisawa, R., Motomura, E., Nakamura, M., Sakamoto, M., Takeya, M., Eto, K. Increased methylmercury toxicity related to obesity in diabetic KK-Ay mice.J. Appl. Toxicol. (2014) Aug;34(8):914-923.
  • Shiraishi, M., Hangai, M., Yamamoto, M., Sasaki, M., Tanabe, A., Sasaki, Y., Miyamoto, A. Alteration in MARCKS phosphorylation and expression by methylmercury in SH-SY5Y cells and rat brain. Environ. Toxicol. Pharmacol. (2014) May;37(3):1256-1263.
  • Yachiguchi, K., Sekiguchi, T., Nakano, M., Hattori, A., Yamamoto, M., Kitamura, K., Maeda, M., Tabuchi, Y., Kondo, T., Kamauchi, H., Nakabayashi, H., Srivastav, AK., Hayakawa, K., Sakamoto, T., Suzuki, N. Effect of inorganic mercury and methylmercury on osteoclasts and osteoblasts in the scales of the marine teleost as a model system of bone. Zoolog. Sci.(2014) May;31(5):330-337.
  • 石橋康弘、山元　恵　「バイオレメディエーションによる水銀汚染環境の浄化」　メタルバイオテクノロジーによる環境保全と資源回収　シーエムシー出版 2014年11月pp251-256.
2015
  • Shao, Y., Yamamoto, M., Figeys, D., Ning, Z., Chan, H. M. Proteomic Analysis of Cerebellum in Common Marmoset Exposed to Methylmercury. Toxicol. Sci. (2015) Jul;146(1):43-
    51. 　　 https://academic.oup.com/toxsci/article/146/1/43/1661267
  • Muniroh, M., Khan, N., Koriyama, C., Akiba, S., Vogel, C. F., Yamamoto, M. Suppression of methylmercury-induced IL-6 and MCP-1 expressions by N-acetylcysteine in U-87MG human astrocytoma cells. Life Sci. (2015) May:134:16-21.
  • 坂本峰至、山元 恵　「水銀の健康影響」生活と環境 日本環境衛生センター　
    2015年5月pp16-22.
2016
  • Shao, Y., Yamamoto, M., Figeys, D., Ning, Z., Chan, H. M. Proteome profiling reveals regional protein alteration in cerebrum of common marmoset (Callithrix jacchus) exposed to methylmercury. Toxicology. (2016) Mar 10; 347-349:29-39.
  • Sakamoto, M., Murata, K., Domingo, J. L., Yamamoto, M., Oliveira, R. B., Kawakami, S., Nakamura, M. Implications of mercury concentrations in umbilical cord tissue in relation to maternal hair segments as biomarkers for prenatal exposure to methylmercury. Environ. Res . (2016) Aug;149:282-287.
  • Yoshimoto, K., Anh, H. T., Yamamoto, A., Koriyama, C., Ishibashi, Y., Tabata, M., Nakano, A., Yamamoto, M. Simple analysis of total mercury and methylmercury in seafood using heating vaporization atomic absorption spectrometry. J. Toxicol. Sci .(2016) 41(4):489-
    500. https://www.jstage.jst.go.jp/article/jts/41/4/41_489/_pdf/-char/en
  • 5th International Conference on Prenatal Programming and Toxicity (PPTOX) V “Poster Award”: https://warp.da.ndl.go.jp/info:ndljp/pid/11958452/www.pu-kumamoto.ac.jp/news/detail.php?id=212
2017
  • Yamamoto, M., Khan, N., Muniroh, M., Motomura, E., Yanagisawa, R., Matsuyama, T., Vogel, C. F. Activation of IL-6 and IL-8 expressions by methylmercury in human U937 macrophages involves RelA and p50. J. Appl. Toxicol. (2017) May;37(5) 611-620.
  • Hoang, VAT., Sakamoto, M., Yamamoto, M. Mercury and selenium levels, and their molar ratios in several species of commercial shrimp in Japan regarding the health risk of methylmercury exposure. J. Toxicol. Sci. (2017) 42(4):509-517.
    https://www.jstage.jst.go.jp/article/jts/42/4/42_509/_pdf/-char/en
  • Hoang, VAT., Do, HTT., Agusa, T., Koriyama, C., Akiba, S., Ishibashi, Y., Sakamoto, M., Yamamoto, M. Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi. J. Toxicol. Sci. (2017) 42(5):651-662.
    https://www.jstage.jst.go.jp/article/jts/42/5/42_651/_pdf/-char/en
  • David, J., Nandakumar, A., Muniroh, M., Akiba, S., Yamamoto, M,. Koriyama, C. Suppression of methylmercury-induced MIP-2 expression by N-acetyl-L-cysteine in murine RAW264.7 macrophage cell line. Eur. J. Med. Res . (2017) 22(1): 45.
2018
  • Tsuji M, Shibata E, Morokuma S, Tanaka R, Senju A, Araki S, Sanefuji M, Koriyama C, Yamamoto M, Ishihara Y, Kusuhara K, Kawamoto T, Japan Environment & Children's Study Group (JECS). The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children’s Study (JECS). Environ Res .2018 June; 166:562-569.
  • Jaingam W, Komorita T, Ishimatsu S, Takenaka R, Umehara A, Kobayashi J, Yamamoto M, Arizono K, Tsutsumi H. Biomagnification Process of Total Mercury in the Macro-benthic Communities in an Enclosed Bay, Isahaya Bay, Kyushu, Japan. Jpn. J. Environ. Toxicol. 2018 Sep 21 (1):9-20.
  • Jaingam W, Komorita T, Ishimatsu S, Kobayashi J, Yamamoto M, Arizono K, Tsutsumi H. Influence of benthic biomagnification process on the total mercury content of fish and mega-benthos in an enclosed bay. Jpn. J. Shiranuikai & Kumagawa Reg. Stud .2018 12(1):3-14.
  • Sakamoto M, Tatsuta N, Izumo K, Phuong PT, Loi VD, Yamamoto M, Nakamura M, Nakai K, Murata K. Health impacts and biomarkers of prenatal exposure to methylmercury. Toxics .2018 Aug 3;6(3). pii: E45.
2019
  • Yamamoto M, Motomura E, Yanagisawa R, Hoang VAT, Mogi M, Mori T, Nakamura M, Takeya M, Eto K. Evaluation of neurobehavioral impairment in methylmercury-treated KK-Ay mice by dynamic weight-bearing test. J Appl Toxicol. 2019 Feb;39(2):221-230.
  • Tsuji M, Koriyama C, Ishihara Y, Yamamoto M, Yamamoto-Hanada K, Kanatani K, Bamai YA, Onishi K, Senju A, Araki S, Shibata E, Morokuma S, Sanefuji M, Kitazawa H, Saito M, Umezawa M, Onoda A, Kusuhara K, Tanaka R, Kawamoto T; Japan Environment & Children’s Study Group. Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study. J Epidemiol. 2019 Dec 5;29(12):478-486.
2020
  • David J, Muniroh M, Nandakumar A, Tsuji M, Koriyama C, Yamamoto M. Inorganic mercury-induced MIP-2 expression is suppressed by N-acetyl-L-cysteine in RAW264.7 macrophages. Biomed. Rep . 2020 Feb; 12 (2):39-45.
  • Muniroh M, Gumay AR, Indraswari DA, Bahtiar Y, Hardian H, Bakri S, Maharani N, Karlowee V, Koriyama C, Yamamoto M. Activation of MIP-2 and MCP-5 Expression in Methylmercury-Exposed Mice and Their Suppression by N-Acetyl-L-Cysteine. Neurotox Res.2020 Feb; 1-8.
  • Haraguchi K, Sakamoto M, Matsuyama A, Yamamoto M, Hung DT, Nagasaka H, Uchida K, Ito Y, Kodamatani H, Horvat M, Chan HM, Rand M, Cirtiu CM, Kim BG, Nielsen F, Yamakawa A, Mashyanov N, Panichev N, Panova E, Watanabe T, Kaneko N, Yoshinaga J, Herwati RF, Suoth AE, Akagi H. Development of human hair reference material supporting the biomonitoring of methylmercury. Anal. Sci . 2020 May; 10;36(5):561-567.
  • Yoshino K, Mori K, Kanaya G, Kojima S, Henmi Y, Matsuyama A, Yamamoto M. Food sources are more important than biomagnification on mercury bioaccumulation in marine fishes.Environ. Pollut. 2020 Jul;262:113982.
  • Sakamoto M, Kakita A, Sakai K, Kameo S, Yamamoto M, Nakamura M. Methylmercury exposure during the vulnerable window of the cerebrum in postnatal developing rats. Environ Res. 2020 Sep;188:109776. doi: 10.1016/j.envres.2020.109776. Epub 2020 Jun 9.
  • Yamamoto M, Yanagisawa R, Sakai A, Mogi M, Shuto S, Shudo M, Kashiwagi H, Kudo M, Nakamura M, Sakamoto M. Toxicokinetics of methylmercury in diabetic KK-Ay mice and C57BL/6 mice. J Appl Toxicol .2020 Oct 5. doi: 10.1002/jat.4078. Online ahead of print.
2021
  • 山元　恵、丸本幸治： 地域発の分析化学「水俣発の水銀分析法」
    ぶんせき：日本分析化学会 2021 ; 1: 21-22.
    https://www.jsac.or.jp/bunseki/pdf/bunseki2021/p21.pdf
  • Oguro A, Fujita K, Ishihara Y, Yamamoto M, Yamazaki T. DHA and its metabolites have a protective role against methylmercury-induced neurotoxicity in mouse primary neuron and SH-SY5Y cells. Int. J. Mol. Sci.2021, 22(6), 3213; https://doi.org/10.3390/ijms22063213
  • Kataoka C, Yoshino K, Kashiwada S, Yamamoto M. Do polystyrene beads contribute to accumulation of methylmercury in oysters?Arch. Environ. Contam. Toxicol.2021 Apr 24. doi: 10.1007/s00244-021-00848-w. in press
  • Yoshino K, Yamada K, Tanaka M, Tada Y, Kanaya G, Henmi Y, Yamamoto M. Subtidal benthic communities in Minamata Bay, Japan, approximately 30 years after mercury pollution remediation involving dredging disturbance. Ecol. Res. 2021. https://doi.org/10.1111/1440-1703.12281
2022
  • Sakamoto M, Haraguchi K, Tatsuta N, Marumoto M, Yamamoto M, Nakamura M. Breast milk contribution to tissue mercury levels in rat pups examined by cross-fostering at birth. Environ Res. 2022 Jan 19;208:112772. doi: 10.1016/j.envres.2022.112772.
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