トップ　＞　組織の案内　＞　国際・総合研究部
坂本　峰至　（さかもと　みねし）
    所長特任補佐
    専門：環境疫学、毒性神経行動学
    メチル水銀の胎児影響に関する研究を5年以上に亘り、主に行ってきました。
    メチル水銀への感受性が最も高い胎児に関する研究では、男児は女児よりメチル水銀汚染に弱く、死産・流産による男児の過剰死が、水俣の男児出生性比を低下させたことを疫学研究で示しました。また、メチル水銀は胎盤を介して能動的に移行し、胎児の血液や脳に母親より高濃度に蓄積すること、母乳からの移行は少ないことを論文にしました。これらの知見は、「胎児への影響を考慮した妊婦への魚介類摂取注意事項」（平成17年厚労省）決定における科学的根拠に採用されました。他方、魚類は児の脳に有益なドコサヘキサエン酸（DHA）を含むので、妊婦は水銀濃度が低くてDHAに富む小魚を食べることが児の脳を守る上で有益であるという提言は、米国化学会サイエンス・ニュースで取り上げられました。
    現在は、長年の謎とされていた、水俣病患者におけるセレン濃度上昇と発症におけるセレンの役目という、水俣病における新たな一面の究明に鋭意努力しています。
    水俣病研究への貢献に加え、国際保健機関（WHO）等の緊急要請に応じて、海外における数多くの水銀汚染問題解決に努めた国際貢献が評価されて、平成29年に人事院総裁賞（個人部門）を受賞しました。
　
    海外調査等：
    WHO要請に基づく現地調査（キルギスタン、カンボジア、インドネシア、モンゴル）、ベトナム国　ハノイ市の工場火災に伴う水銀汚染調査協力
    JICA協力（フィリピン、ブラジル、バングラデシュ）、国際共同研究（ブラジル、中国、アメリカ、カナダ、スロベニア、スペイン、 フィリピン、イタリア、ベトナム、モンゴル）
今年度の研究テーマ・担当業務（代表のみ）
  • 水俣病における水銀とセレンの共存及びメチル水銀の胎・乳児影響に関する研究（RS-22-05）
  • 科研費基盤研究（C）「メチル水銀毒性のセレンによる抑制：水俣病発生当時の環境・患者試料を用いた新規解析」
所属している研究グループ
    リスク評価グループ
外部資金による研究（代表のみ）
  • 胎児期に受けたメチル水銀の神経系及び生理的老化に及ぼす後影響に関する研究（科研費）
  • 発達期脳へのメチル水銀毒性に関する食物由来セレン化合物の抑制機構に関する研究（科研費）
  • 水俣湾埋め立て地に眠るヘドロ中水銀の化学形態別分析によるリスク評価（科研費）
主な履歴、学歴、学位、表彰等
  • 医学博士
  • 客員教授：東北大学大学院医学系研究科（2018～2020年度）、ブラジル・パラ州立西部大学（2014～2016）、熊本県立大学（2014～2019年度）
  • 客員准教授：熊本大学大学院医学教育部（2013年度～継続中）
  • 非常勤講師：三重大学医学系研究科・医学部（2017年度～継続中）、熊本大学薬学教育部（2017年度～継続中）
  • 客員研究員：鹿児島大学大学院医歯学総合研究科（2017年度～継続中）
  • 学会活動：Editorial Board Member :Environ Res (2014～),日本衛生学会編集委員 (平成17-19年)、日本衛生学会 評議員（2005年度～継続中）、国際水銀会議・実行委員(2007～2018)
  • 所属学会：日本衛生学会、日本微量元素学会
  • 第29回　人事院総裁賞（個人部門）(2017年2月)
主な研究業績
英文：論文・原著、総説（現在⇒過去）

  • Sakamoto M, Haraguchi K, Tatsuta N, Marumoto M, Yamamoto M, Nakamura M. Breast milk contribution to tissue mercury levels in rat pups examined by cross-fostering at birth. Environ Res. (IF=6.498) 2022 Jan 19; 208: 112772. Online first.
  • Marumoto M, Sakamoto M, Nakamura M, Marumoto K, Tsuruta S. Organ-specific accumulation of selenium and mercury in Indo-Pacific bottlenose dolphins (Tursiops aduncus). Acta Vet Scand. (IF=1.695) 2022 Jan 27; 64(1): 1.
  • Sakamoto M, Haraguchi K, Tatsuta N, Nakai K, Nakamura M, Murata K. Plasma and red blood cells distribution of total mercury, inorganic mercury, and selenium in maternal and cord blood from a group of Japanese women. Environ Res. (IF=6.498) 2021 May; 196: 110896.
  • Sakamoto M, Kakita A, Sakai K, Kameo S, Yamamoto M, Nakamura M. Methylmercury exposure during the vulnerable window of the cerebrum in postnatal developing rats. Environ Res. (IF=6.498) 2020 Sep; 188: 109776.
  • Sakamoto M, Itai T, Marumoto K, Marumoto M, Kodamatani H, Tomiyasu T, Nagasaka H, Mori K, Poulain AJ, Domingo JL, Horvat M, Matsuyama A: Mercury speciation in preserved historical sludge: Potential risk from sludge contained within reclaimed land of Minamata Bay, Japan. Environ Res. (IF=6.498), 2020 Jan; 180: 108668. (JSPS KAKENHI Grant Number JP15K00533)
  • Yamamoto M, Yanagisawa R, Sakai A, Mogi M, Shuto S, Shudo M, Kashiwagi H, Kudo M, Nakamura M, Sakamoto M. Toxicokinetics of methylmercury in diabetic KK-Ay mice and C57BL/6 mice. J Appl Toxicol (IF=3.446). 2020 Oct 5.
  • Tatsuta N, Nakai K, Kasanuma Y, Iwai-Shimada M, Sakamoto M, Murata K, Satoh H. Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children. Environ Res. (IF=6.498) 2020 Oct; 189: 109844.
  • Marumoto M, Sakamoto M, Marumoto K, Tsuruta S, Komohara Y. Mercury and Selenium Localization in the Cerebrum, Cerebellum, Liver, and Kidney of a Minamata Disease Case. Acta Histochem Cytochem. (IF=1.75) 2020; 53 (6): 147–155.
  • Haraguchi K, Sakamoto M, Matsuyama A, Yamamoto M, Hung DT, Nagasaka H, Uchida K, Ito Y, Kodamatani H, Horvat M, Chan HM, Rand M, Cirtiu CM, Kim BG, Nielsen F, Yamakawa A, Mashyanov N, Panichev N, Panova E, Watanabe T, Kaneko N, Yoshinaga J, Herwati RF, Suoth AE, Akagi H. Development of Human Hair Reference Material Supporting the Biomonitoring of Methylmercury. Anal Sci. 2020 May 10;36 (5):561-567.
  • Maeda E, Murata K, Kumazawa Y, Sato W, Shirasawa H, Iwasawa T, Izumo K, Tatsuta N, Sakamoto M, Terada Y. Associations of environmental exposures to methylmercury and selenium with female infertility: A case-control study. Environ Res. (IF=6.498) 2019 Jan; 168: 357-363.
  • Sakamoto M, Tatsuta N, Chan HM, Domingo JL, Murata K, Nakai K. Brain methylmercury uptake in fetal, neonate, weanling, and adult rats. Environ Res. (IF=6.498) 2018 Nov; 167: 15-20.
  • Karita K, Iwata T, Maeda E, Sakamoto M, Murata K. Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity. Toxics (IF=4.146). 2018 Jul 20; 6(3). pii: E38.
  • Sakamoto M, Chan HM, Domingo JL, Koriyama C, Murata K. Placental transfer and levels of mercury, selenium, vitamin E, and docosahexaenoic acid in maternal and umbilical cord blood. Environ Int. (IF=9.621) 2018 Feb; 111:309-315.
  • Sakamoto M, Tatsuta N, Izumo K, Phan P T, Vu L D, Yamamoto M, Nakamura M, Nakai K, Murata K. Health impacts and biomarkers of prenatal exposure to methylmercury: Lessons from Minamata, Japan Toxics (IF=4.146). 2018 Aug 3;6(3):45
  • Tatsuta N, Nakai N, Sakamoto M, Murata K, Satoh H. Methylmercury exposure and developmental outcomes in Tohoku Study of Child Development at 18 months of age.Toxics (IF=4.146) 2018, 6(3), 49
  • Hoang VAT, Sakamoto M, Yamamoto M. Mercury and selenium levels, and their molar ratios in several species of commercial shrimp in Japan regarding the health risk of methylmercury exposure. J Toxicol Sci. (IF=1.719) 2017; 42(4):509-517.
  • Hoang VAT, Do HTT, Agusa T, Koriyama C, Akiba S, Ishibashi Y, Sakamoto M, Yamamoto M. Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi. J Toxicol Sci. (IF=1.719) 2017; 42(5):651-662.
  • Sakamoto M, Kakita A, Domingo JL, Yamazaki H, Oliveira R, Sarrazine S, Eto K, Murata K. Stable and episodic/bolus patterns of methylmercury exposure on mercury accumulation and histopathologic alterations in the nervous system. Environ Res. (IF=6.498) 2017 Jan; 152: 446-453.
  • Ser PH, Omi S, Shimizu-Furusawa H, Yasutake A, Sakamoto M, Hachiya N, Konishi S, Nakamura M, Watanabe C. Differences in the responses of three plasma selenium-containing proteins in relation to methylmercury-exposure through consumption of fish/whales. Toxicol Lett. (IF=3.166) 2017 Feb 5; 267:53-58.
  • Ha E, Basu N, Bose-O'Reilly S, Dórea JG, McSorley E, Sakamoto M, Chan HM. Current progress on understanding the impacts of mercury on human health. Environ Res. (IF=6.498) 2017 Jan; 152:419-433.
  • Iwata T, Takaoka S, Sakamoto M, Maeda E, Nakamura M, Liu XJ, Murata K. Characteristics of hand tremor and postural sway in patients with fetal-type Minamata disease. J Toxicol Sci. (IF=1.719) 2016; 41(6):757-763.
  • Sakamoto M, Murata K, Domingo JL, Yamamoto M, Oliveira RB, Kawakami S, Nakamura M. Implications of mercury concentrations in umbilical cord tissue in relation to maternal hair segments as biomarkers for prenatal exposure to methylmercury. Environ Res. (IF=6.498) 2016 Aug; 149:282-7.
  • Sakamoto M, Chan HM, Domingo JL, Oliveira RB, Kawakami S, Murata K. Significance of fingernail and toenail mercury concentrations as biomarkers for prenatal methylmercury exposure in relation to segmental hair mercury concentrations. Environ Res. (IF=6.498) 2015 Jan; 136:289-94.
  • Sakamoto M, Itai T, Yasutake A, Iwasaki T, Yasunaga G, Fujise Y, Nakamura M, Murata K, Chan HM, Domingo JL, Marumoto M. Mercury speciation and selenium in toothed-whale muscles. Environ Res. (IF=6.498) 2015 Nov; 143(Pt A):55-61.
  • Ilmiawati C, Yoshida T, Itoh T, Nakagi Y, Saijo Y, Sugioka Y, Sakamoto M, Ikegami Ogawa A, M, Kayama F. Biomonitoring of mercury, cadmium, and lead exposure in Japanese children: a cross-sectional study. Environ Health Prev Med. (IF=3.674) 2015 Jan; 20(1):18-27.
  • Yamamoto M, Yanagisawa R, Motomura E, Nakamura M, Sakamoto M, Takeya M, Eto K. Increased methylmercury toxicity related to obesity in diabetic KK-Ay mice. J Appl Toxicol. (IF=3.446) 2014 Aug; 34(8):914-23.
  • Nakamura M, Hachiya N, Murata KY, Nakanishi I, Kondo T, Yasutake A, Miyamoto K, Ser PH, Omi S, Furusawa H, Watanabe C, Usuki F, Sakamoto M. Methylmercury exposure and neurological outcomes in Taiji residents accustomed to consuming whale meat. Environ Int. (IF=9.621) 2014 Jul; 68:25-32.
  • Arai K, Maeda E, Iwata T, Tanaka O, Murata K and Sakamoto M. Impact of dietary behaviors on dyslipidemia in Japanese male workers. Ann Transl Med Epidemiol. 2014; 1(1):1003.
  • Sakamoto M, Yasutake A, Domingo JL, Chan HM, Kubota M, Murata K. Relationships between trace element concentrations in chorionic tissue of placenta and umbilical cord tissue: Potential use as indicators for prenatal exposure. Environ Int. (IF=9.621) 2013 Sep 9; 60C: 106-111.
  • Horvat M, Sakamoto M, Chan L, Faganeli J. Mercury in contaminated sites: identification, characterization, impacts, and remediation. Environ Res. (IF=6.498) 2013 Aug; 125:1.
  • Sakamoto M, Yasutake A, Kakita A, Ryufuku M, Chan HM, Yamamoto M, Oumi S, Kobayashi S, Watanabe C. Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat cerebrum. Environ Sci Technol. (IF=9.028). 2013 Mar 19; 47(6):2862-8.
  • Sakamoto M, Chan HM, Domingo JL, Kubota M, Murata K. Changes in body burden of mercury, lead, arsenic, cadmium and selenium in infants during early lactation in comparison with placental transfer. Ecotox Environ Safety (IF=6.291) 2012 Oct; 84:179-84.
  • Sakamoto M, Murata K, Kakita A, Sasaki M. A review of mercury toxicity with special reference to methylmercury, in：Advances in Environmental Chemistry and Toxicology of Mercury (Cai Y, Liu G, O'Driscoll N eds.), Wiley-VCH (Weinheim), 2012 pp. 501-516 Chapter 15.
  • Murata K, Sakamoto M. Minamata disease.In: Nriagu JO(ed.) Encyclopedia of Environmental Health, 2012 vol 3:774-780, Burlington: Elsevier.
  • Sakamoto M, Chan HM, Domingo JL, Kawakami S, Murata K. Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition. Environ Int. (IF=9.621)) 2012 Sep; 44:112-7.
  • Steckling N, Boese-O'Reilly S, Sakamoto M(12th), (他16名). Mercury exposure in female artisanal small-scale gold miners (ASGM) in Mongolia: An analysis of human biomonitoring (HBM) data from 2008. Sci Total Environ. (IF=7.963) 2011 Feb 1; 409(5):994-1000.
  • Sakamoto M, Murata K, Tsuruta K, Miyamoto K, Akagi H. Retrospectve study on temporal and regional variations of methylmercury concentrations in preserved umbilical cords collected from inhabitants of the Minamata area, Japan. Ecotox Environ Safety (IF=6.291). 2010 Sep; 73(6):1144-9.
  • Sakamoto M Murata K, Kubota M, Nakai K, Satoh H. Mercury and heavy metal profiles of maternal and umbilical cord RBCs in Japanese population. Ecotox Environ Safety (IF=6.291) 2010 Jan; 73(1):1-6.
  • Cheng J, Yang Y, Ma J, Wang W, Liu X, Sakamoto M, Qu Y, Shi W. Assessing noxious effects of dietary exposure to methylmercury, PCBs and Se coexisting in environmentally contaminated rice in male mice. Environ Int. (IF=9.621). 2009 Apr; 35(3):619-25.
  • Cheng J, Gao L, Zhao W, Liu X, Sakamoto M, Wang W. Mercury levels in fisherman and their household members in Zhoushan, China: impact of public health. Sci Total Environ. (IF=7.963) 2009 Apr 1;407(8):2625-30.
  • Sakamoto M, Kubota M, Murata K, Nakai K, Sonoda I, Satoh H. Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population. Environ Res. (IF=6.498). 2008 Feb;106(2):270-6.
  • Liu X, Cheng J, Song Y, Honda S, Wang L, Liu Z, Sakamoto M, Liu Y. Mercury concentration in hair samples from Chinese people in coastal cities. J Environ Sci (China). 2008;20(10):1258-62.
  • Carratù MR, Coluccia A, Modafferi AM, Borracci P, Scaccianoce S, Sakamoto M, Cuomo V. Prenatal methylmercury exposure: effects on stress response during active learning. Bull Environ Contam Toxicol. (IF=2.151) 2008 Dec;81(6): 539-42.
  • Li P, Feng X, Qiu G, Li Z, Fu X, Sakamoto M, Liu X, Wang D. Mercury exposures and symptoms in smelting workers of artisanal mercury mines in Wuchuan, Guizhou, China. Environ Res. (IF=6.498) 2008;107(1):108-14.
  • Iwata T, Sakamoto M, Feng X, Yoshida M, Liu XJ, Dakeishi M, Li P, Qiu G, Jiang H, Nakamura M, Murata K. Effects of mercury vapor exposure on neuromotor function in Chinese miners and smelters. Int Arch Occup Environ Health (IF=3.015) 2007 Apr; 80(5):381-7.
  • Ohno T, Sakamoto M, Kurosawa T, Dakeishi M, Iwata T, Murata K. Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function. Environ Res. (IF=6.498) 2007 Feb;103(2):191-7.
  • Mergler D, Anderson A H, Chan LHM, Mahaffey KR., Murray M, Sakamoto M, Stern A H. Methylmercury Exposure and Health Effects in Humans: A Worldwide Concern. The Panel on Health Risks and Toxicological Effects of Methylmercury: AMBIO (IF=3.616) 2007 Feb;36(1):3-11.
  • Sakamoto M, Feng X, Li O, Qiu G, Jiang H, Yoshida M, Iwata T, Liu XJ, Murata K. High exposure of Chinese mercury mine workers to elemental mercury vapor and increased methylmercury levels in their hair. Environ Health Prev Med. (IF=3.674) 2007;12(2):66-70.
  • Sakamoto M, Kaneoka T, Murata K, Nakai K, Satoh H. Akagi H. Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population. Environ Res. (IF=6.498) 2007;103(1):106-11.
  • Honda S, Hylander L, Sakamoto M. Recent advances in evaluation of health effects on mercury with special reference to methylmercury-A Minireview. Environ Health Prev Med. (IF=3.674) 2006 Jul;11(4):171-6.
  • Vu Duc Loi, Le Lan Anh, Trinh Anh Duc, Trinh Xuan Gian, Pham Gia Mon, Tran Van Huy, Nguyen Quoc Thong, Alian Boudou, Sakamoto M, Dao Van Bay. Contamination by cadmium and mercury of the water, sediment and biological component of hydrosystems around Hanoi. J Chemistry 2006; 44:382-386.
  • Murata K, Sakamoto M, Nakai K, Dakeishi M, Iwata T, Liu XJ, et al. Subclinical effects of prenatal methylmercury exposure on cardiac autonomic function in Japanese children. Int Arch Occup Environ Health (IF=3.015) 2006 Jan; 11(1):17-23.
  • Iwata T, Nakai K, Sakamoto M, Dakeishi M, Satoh H, Murata K. Factor affecting hand tremor and postural sway in children. Environ Health Prev Med. (IF=3.674) 2006 Jan;11(1):17-23.
  • Sakamoto M, Yasutake A, Satoh H. Methylmercury exposure in general populations of Japan, Asia and Oceania. Dynamics of mercury pollution on regional and global scales: atmospheric processes and human exposures around the world. N. Pirrone & K.R. Mahaffey (Eds) Springer 2005 p125-146.
  • Sakamoto M, Murata K, Nakai K, Satoh H. Difference in methylmercury exposure to fetus and breast-feeding offspring: a mini-review. Kor J Env Hlth. 2005; 31:179-186.
  • Pan HS, Sakamoto M, Liu XJ, Futatsuka M. Deficits in rat brain growth induced by methylmercury treatment during the brain growth spurt. J Health Sci. 2005 51(1):1-7.
  • Dakeishi M, Nakai K, Sakamoto M, Iwata T, Suzuki K, Liu X, et al. Effects of hair treatment on hair mercury - The best biomarker of methylmer5cury exposure? Environ Health Prev Med. (IF=3.674) 2005 Jul;10(4):208-12.
  • Sakamoto M, Kubota M, Liu XJ, Murata K, Nakai K, Satoh H. Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus. Environ Sci Technol. (IF=9.028) 2004;38:3860-3863.
  • Sakamoto M, Kakita A, Oliveira RB, Pan HS, Takahashi H. Dose-dependent effects of methylmercury administered during neonatal brain spurt in rats. Dev Brain Res (IF=2.746) 2004;152:171-176.
  • Murata K, Sakamoto M, Nakai K, Weihe P, Dakeishi M, Iwata T, Liu XJ, Ohno T, Kamiya K, Satoh H. Effects of methylmercury on neurodevelopment in Japanese children in relation to Madeiran study. Int Arch Occup Environ Health (IF=3.015) 2004;77:571-579.
  • Sakamoto M, Kubota M, Liu XJ, Murata K, Nakai K, Satoh H. Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus. Environ Sci Technol. (IF=9.028) 2004;38:3860-3863.
  • Nakai K, Suzuki K, Oka T, Murata K, Sakamoto M, Okamura K, HosokawaT, Sakai T, Nakamura T, Saitoh Y, Kurokawa N, Kameo S, Satoh H. A Cohort study of effects of perinatal exposures to methylmercury and environmentally persistent organic pollutants on neurobehavioral development in Japanese children. Tohoku J Exp Med. (IF=1.423) 2004;202:227-237.
  • Pan HS, Sakamoto M, Oliveira RB, Liu XJ, Kakita A, Futatsuka M. Changes in methylmercury accumulation in the brain of rat offspring throughout gestation and during suckling. Toxicol Environ Chem. (IF=0.972) 2004;86:163-170.
  • Sakamoto M, Kubota M. Plasma fatty acid profiles in 38 pairs of maternal and umbilical cord blood samples. Environ Health Prev Med. (IF=3.674) 2004 Mar;9(2):67-9.
  • Iwasaki Y, Sakamoto M, Nakai K, Oka T, Deshimaru M, Iwata T, Satoh H, Murata K. Estimation of daily mercury intake from seafood in Japanese women: Akita Cross-Sectional Study. Tohoku J Exp Med (IF=1.423) 2003; 200:67-73.
  • Kakita A, Inenaga C, Sakamoto M, Takahashi H. Disruption of postnatal progenitor migration and consequent abnormal pattern of glial distribution in the cerebral cortex following administration of methylmercury. J Neuropathol Exp Neurol. (IF=3.490) 2003;62(8):835-847.
  • Kakita A, Inenaga C, Sakamoto M, Takahashi H. Neuronal migration disturbance and consequent cyoarchitecture in the cerebral cortex following transplacental administration of methylmercury. Acta Neuropathol. (IF=17.088) 2003;104(4):409-417.
  • Sakamoto M, Kubota M, Matsumoto S, Nakano A, Akagi H. Declining risk of methylmercury exposure to infants during lactation. Environ Res. (IF=6.498) 2003:90 (3):185-189.
  • Kakita A, Inenaga C, Sakamoto M, Takahashi H. Neuronal migration disturbance and consequent cytoarchitecture in the cerebral cortex following transplacental administration of methylmercury. Acta Neuropathol. (IF=15.872) 2002;104:409-417.
  • Sakamoto M, Kakita A, Wakabayashi K, Takahashi H, Nakano A, Akagi H. Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods. Brain Res. (IF=3.125) 2002;949:51-59.
  • Sakamoto M, Nakano A, Akagi H. Declining. Minamata male birth ratio associated with increased male fetal death due to heavy methylmercury pollution. Environ Res. (IF=6.498) Section A 2001;87:92-98.
  • Kakita A, Wakabayashi K, Su M, Sakamoto M, Ikuta F, Takahashi H. Intrauterine methylmercury intoxication: pattern of neuronal degeneration in the fetal brain and consequence on higher brain function in maturity. In: Takizawa Y and Osame M (eds.), Understanding of Minamata Disease. Methylmercury Poisoning in Minamata and Niigata, Japan. The Japan Public Health Association, Tokyo, 2001. pp.85-93.
  • Kakita A, Wakabayashi K, Su M, Sakamoto M, Ikuta F, Takahashi H. Distinct pattern of neuronal degeneration in the fetal rat brain induced by consecutive transplacental administration of methylmercury. Brain Res. (IF=3.252) 2000;859:233-239.
  • Kakita A, Wakabayashi K, Su M, Yoneoka Y, Sakamoto M, Ikuta F, Takahashi H. Intrauterine methylmecury intoxication Consequence of the inherent brain lesions and cognitive dysfunction in maturity. Brain Res. (IF=3.252) 2000; 877:322-330.
  • Fukuda Y, Ushijima K, Kitano T, Sakamoto M, Futatsuka M. An analysis of subjective complaints in a population living in a methylmercury-polluted area. Environ Res. (IF=6.498) Section A 1999;81:100-107.
  • Oyama Y, Nakata M, Sakamoto M, Chikahisa L, Miyoshi N, Satoh M. Methylmercury toxicity in dissociated rat brain neurons: modification by L-cysteine and trimethylbenzylmercaptan and comparison with dimethylmercury and N-ethylmaleimide. Environ Toxicol & Pharmacol. (IF=2.776) 1998;6:221-227.
  • Sakamoto M, Wakabayashi K, Kakita A, Takahashi H, Adachi T, Nakano A. Widespread neuronal degeneration in rats following oral administration of methylmercury during the postnatal developing phase: a model of fetal-type Minamata Disease. Brain Res. (IF=3.252) 1998;784:351-354.
  • Okazaki E, Oyama Y, Chikahisa L, Nagano T, Katayama N, Sakamoto M. Fluorescent estimation on cytotoxicity of methylmercury in dissociated cerebellar neurons: its comparison with ionomycin. Environ Toxicol & Pharmacol. (IF=2.776) 1997;3:237.
  • Sakamoto M, Ikegami N, Nakano A. Protective Effects of Ca2+ Channel Blockers against Methyl Mercury Toxicity. Pharmacol & Toxicol. (IF=2.659) 1996;78:193-199.
  • Wakabayashi K, Kakita A, Sakamoto M, Su M, Iwanaga K, Ikuta F. Variability of brain lesions in rats administered methylmercury at various postnatal development phases. Brain Res. (IF=3.252) 1995;705:267-272.
  • Sakamoto M, Nakano A. Comparison of mercury accumulation among the brain, liver, kidney, and the brain regions of rats administered methylmercury in Various Phases of Postnatal Development. Bull Environ Contam Toxicol (IF=2.151) 1995;55:588-596.
  • Kinjo Y, Higashi H, Nakano A, Sakamoto M, Sakai R. Profile of Subjective Complaints and Activities of Daily Living among Current Patients with Minamata Disease after 3 Decades. Environ Res. (IF=6.498) 1993;63:241-251.
  • Sakamoto M, Nakano A, Kajiwara Y, Naruse I, Fujisaki T. Effects of methyl mercury in postnatal developing rats. Environ Res. (IF=6.498) 1993;61:43-50.
  • Kinjo Y, Nakano A, Sakamoto M, Futatsuka M, Kato H. Clarification of mortality patterns among Minamata Disease patients. Environ Sci 1991;1(2):73-88.
  • Sakamoto M, Nakano A, Kinjo Y, Higashi H, Futatsuka M. Present mercury levels in red blood cells of nearby inhabitants about 30 years after the outbreak of Minamata Disease. Ecotox Environ Safety (IF=6.291), 1991;22:58-66.
  • Wakisaka I, Yanagihashi T, Nakano A, Sakamoto M. Interaction of sulfur dioxide and nicotine aerosol as sensory irritants. Acta Med Univ Kagoshima 1990;42(1): 59-67.
  • Nakamura K, Sakamoto M, Uchiyama H, Yagi O. Organomercurial-volatilizing bacteria in the mercury-polluted sediment of Minamata Bay, Japan. Appl & Environ Microbiology (IF=4.792) 1990;56(1):304-305.
  • Ando T, Sakamoto M, Yanagihashi T. Effect of methylmercury on the lipid components in rats. Acta Med Univ Kagoshima 1987;29(2):67-74.
  • Kanazawa A, Teshima S, Sakamoto M Effect of dietary lipids, fatty acids, and phospholipids on growth and survival of prawn (penaeus japonicus) larvae. Aquaculture (IF=4.242)1985; 50:39-49.
  • Sakamoto M. Effect of methylmercury on the lipid composition in guinea pigs. Industrial Health 1985, 23, 171-179.
  • Sakamoto M, Holland DL, Jones DA. Modification of the nutritional composition of Artemia by incorporation of polyunsaturated fatty acids using micro-encapsulated diets. Aquaculture (IF=4.242) 1982; 28:311-320.
  • Kanazawa A, Teshima S, Sakamoto M. Requirements of essential fatty acids for the larval Ayu. Bull Jap Soc Sci Fisheries 1982;48(4):587-590.
  • Teshima S, Kanazawa A, Sakamoto M. Essential fatty acids of Tilapia nilotica. Mem. Fac. Fish., Kagoshima Univ 1982;31:201-204.
  • Kanazawa A, Teshima S, Sakamoto M, Shinomiya A. Nutritional requirements of the puffer fish: purified test diet and the optimum protein level. Bull Jap Soc Sci Fisheries 1980;40(11):1957-1961.
  • Kanazawa A, Teshima S, Sakamoto M, Md. Awal A. Requirements of Tilapia zillii for essential fatty acids. Bull Jap Soc Sci Fisheries 1980;40(11):1353-1356.
和文：論文原著・著書（現在⇒過去）

  • 坂本峰至, 柿田明美, 中村政明．「メチル水銀」　 脳の発生とその異常－D.外的要因による異常．　 CLINICAL NEUROSCIENCE 2020 Dec; 38(12): 1594-1597.
  • 上田佳穂, 萩原央記, 坂本峰至, 南武志. Dimercaptosuccinic acidはメチル水銀投与で生じるマウス第三脳室上衣細胞繊毛運動の減少を抑制する. BIOMEDICAL RESEARCH ON TRACE ELEMENTS 2018; 29(2/3): 119-131.
  • 坂本峰至, 中村政明, 村田勝敬. 地球規模汚染物質としての水銀とその曝露評価および健康影響. 日本衛生学雑誌, 2018; 73(3): 258-264.
  • 斉藤　貢, 坂本峰至.水銀に関する水俣条約. 環境による健康リスク I 環境問題の基礎. 日本医師会雑誌 2017; 146 特別号(2): 67-70.
  • 坂本峰至, 村田勝敬. 水俣病. 環境による健康リスク IV 環境汚染による健康障害事例. 日本医師会雑誌2017; 146 特別号(2): 296-299.
  • 坂本峰至, 板井啓明, 村田勝敬. メチル水銀の胎児期曝露影響－水俣病から環境保健学研究へ－. 日本衛生学会雑誌 2017; 72(3): 170-148.
  • 苅田香苗，坂本峰至，吉田　稔，龍田　希，仲井邦彦，岩井美幸，岩田豊人，前田恵理，柳沼　梢，佐藤　洋，村田勝敬. メチル水銀，水銀およびセレンに関する研究動向―疫学研究を中心に―. 日本衛生学会誌 2016; 71: 236–251.
  • 坂本峰至、村田勝敬. 第2章 地球規模での水銀汚染と生体影響. 水銀に関する水俣条約と最新対策・技術. 高岡昌輝 監修. シーエムシー出版. 2014 Nov. pp15-22.
  • 臼杵扶佐子、坂本峰至. 胎児におけるメチル水銀中毒症. 神経症候群（第2版）IV－その他の神経疾患を含めて－. 日本臨牀 2014 09.819-822.坂本峰至、村田勝敬. 水銀の毒性―汚染の歴史と研究の現状―. 環境技術. 2013 Oct; 42(10):584-589.
  • 坂本峰至、山元 恵. 食品中の微量元素 必須元素から放射能核種まで 第8章 水銀（メチル水銀）. 日本食品衛生協会　編. 2013 04.
  • 坂本峰至、山本 恵: 微量元素をめぐる動向3 水銀（メチル水銀）. 食品衛生研究. 2010; 60(12):35-41.
  • 坂本峰至、佐々木眞敬: メチル水銀. 広範囲血液・尿化学検査、免疫学的検査(2)－その数値をどう読むか－、日本臨床 68巻増刊号 2010; 1:576-580.
  • 坂本峰至: メチル水銀. 食品安全ハンドブック. 食品安全編集委員会編. 丸善. 2010. pp118-120.
  • 村田勝敬、坂本峰至、佐藤　洋: メチル水銀曝露の多様性と健康リスク、特集；環境リスク、公衆衛生 2010;74: 279-283.
  • 坂本峰至、安武 章: 魚介類とメチル水銀について. モダンメディア. 57(3), 16-21, 2011.
  • 劉　暁潔、坂本峰至、加藤たけ子、岡本美和子、有村公良. 胎児性水俣病患者の現在のActivity of Daily Living (ADL) 実態と15年前との比較およびコミュニケーション障害に関する研究　日本衛生学雑誌2007; 62(3):905-910.
  • 坂本峰至、赤木洋勝. 水銀の毒性と健康影響. 廃棄物学会誌. 2005; 6:185-190.
  • 坂本峰至、赤木洋勝. 無機・有機水銀（水環境ハンドブック）日本水環境学会. 朝倉書店. 2006. pp352-355.
  • 坂本峰至、衞藤光明. 成人においても微量のメチル水銀は危険なのか？医学のあゆみ 2004;211:1155-1156.
  • 坂本峰至、赤木洋勝. メチル水銀（広範囲血液・尿化学検査・免疫学的検査－その数値をどう読むか－） 日本臨床62巻増刊号2004;12:529-532.
  • 坂本峰至. 海を渡った産業廃棄物－カンボジアで見たもの－. 産廃処理の総合専門誌 INDUST. 1999; 142:36-38.
  • 坂本峰至、中野篤浩、赤木洋勝. 赤血球中水銀濃度の意味－メチル水銀汚染指標から魚介類摂取量指標へ－. FFI JOURNAL 1996; 167:109-115.
  • 坂本峰至、中野篤浩、金城芳秀、若宮純司、藤崎　正、東　博文、北野隆雄、二塚　信. 一般住民検診における過酸化脂質値（血漿TBA値）についての断面研究. 日本公衆衛生雑誌 1992;39(7):399-409.
  • 金城芳秀、中野篤浩、坂本峰至、渡邊正夫、二塚　信、加藤寛夫. 水俣病認定患者の死亡構造に関する追跡調査研究－死亡率および標準化死亡比（SMR）による検討－ 保健の科学 1991;33(8):579-583
  • 坂本峰至、中野篤浩、金城芳秀、東　博文、二塚　信. 一般健康診査における愁訴と動脈硬化指数との関連性. 民族衛生 1990;56(2):87-96.
  • 清水利之、東　博文、高瀬千義、坂本峰至. Fitness Analyzer BFT-2000による体脂肪測定方法の検討. 保健の科学 1990;32(12):848-849.
  • 安藤哲夫、脇阪一郎、柳橋次雄、坂本峰至. ラットにおけるメチル水銀投与と脂質過酸化. 日本衛生学雑誌 1989;44(3):733-738.
  • 安藤哲夫、柳橋次雄、脇阪一郎、坂本峰至. メチル水銀投与ラットにおける脂質過酸化および脂肪酸組成. 日本衛生学雑誌 1989;44(5):993-1001.
  • 坂本峰至、脇阪一郎、安藤哲夫、柳橋次雄. ラットの組織における脂質過酸化及び水銀の蓄積に及ぼす食餌性脂質の影響. 日本衛生学雑誌 1988;43(4):917-922.
  • 安藤哲夫、脇阪一郎、柳橋次雄、坂本峰至. ラットにおける水銀の蓄積および排泄に及ぼすエタノールの影響. 日本衛生学雑誌 1988;43(4): 717-723.
  • 坂本峰至. メチル水銀中毒に及ぼす食餌性脂質の影響. 日本衛生学雑誌 1986:40(66):903-909.
  • 坂本峰至. 喫煙者及び非喫煙者の呼気中のエタン量. 日本衛生学雑誌 1985;40(5):835-840.
  • 脇阪一郎、柳橋次雄、泊　惇、安藤哲夫、坂本峰至. 桜島火山活動が死亡像にあたえる影響. 日本公衆衛生誌 1984;31(10):548-556.